Lysosomes were once considered the end point of endocytosis, simply used for
macromolecule degradation. They are now recognized to be dynamic organelles, able to …

Perforin/granzyme-induced apoptosis is the main pathway used by cytotoxic lymphocytes to
eliminate virus-infected or transformed cells. Studies in gene-disrupted mice indicate that …

Lysosome‐related organelles (LROs) comprise a diverse group of cell type‐specific,
membrane‐bound subcellular organelles that derive at least in part from the endolysosomal …

Virtually all of the measurable cell-mediated cytotoxicity delivered by cytotoxic T
lymphocytes and natural killer cells comes from either the granule exocytosis pathway or the …

Cytotoxic T cells and natural killer cells are crucial for immune surveillance against virus-
infected cells and tumour cells. Molecular studies of individuals with inherited defects that …

Secretion of cytolytic granules content at the immunological synapse is a highly regulated
process essential for lymphocyte cytotoxicity. This process requires the rapid transfer of …

Regulated secretion of stored secretory products is important in many cell types. In contrast
to professional secretory cells, which store their secretory products in specialized secretory …

Rab proteins are small GTP-binding proteins that form the largest family within the Ras
superfamily. Rab proteins regulate vesicular trafficking pathways, behaving as membrane …

Senescent cells accumulate in tissues over time, favoring the onset and progression of
multiple age‐related diseases. Senescent cells present a remarkable increase in lysosomal …

Regulated exocytosis of secretory granules or dense-core granules has been examined in
many well-characterized cell types including neurons, neuroendocrine, endocrine, exocrine …