The brain is a highly energy-demanding organ and requires bioenergetic adaptability to
balance normal activity with pathophysiological fuelling of spontaneous recurrent seizures …

Epilepsy affects~ 65 million people worldwide. First-line treatment options include> 20
antiseizure medications, but seizure control is not achieved in approximately one-third of …

Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …

Considering the lack of a comprehensive, multi-faceted overview of the ketogenic diet (KD)
in relation to health issues, we compiled the evidence related to the use of the ketogenic diet …

High-fat, low-carbohydrate diets, known as ketogenic diets, have been used as a non-
pharmacological treatment for refractory epilepsy. A key mechanism of this treatment is …

Adenosine is a key metabolic and immune-checkpoint regulator implicated in the tumor
escape from the host immune system. Major gaps in knowledge that impede the …

The most common forms of acquired epilepsies arise following acute brain insults such as
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for …

New insights into the mechanisms of the ketogenic diet : Current Opinion in Neurology New
insights into the mechanisms of the ketogenic diet : Current Opinion in Neurology Log in or …

The importance of adenosine for human health cannot be overstated. Indeed, this ubiquitous
nucleoside is an integral component of ATP, and regulates the function of every tissue and …

Although cancer is still one of the most significant global challenges facing public health, the
world still lacks complementary approaches that would significantly enhance the efficacy of …