The potential roles of breast cancer stem cells (BCSCs) in tumor initiation and recurrence
have been recognized for many decades. Due to their strong capacity for self-renewal and …

Ubiquitin–proteasome system (UPS) is a selective proteolytic system that is associated with
the expression or function of target proteins and participates in various physiological and …

Abstract The methyltransferase like 3 (METTL3) has been generally recognized as a nuclear
protein bearing oncogenic properties. We find predominantly cytoplasmic METTL3 …

Background Accumulating evidence has demonstrated that aberrant expression of
deubiquitinating enzymes is associated with the initiation and progression of Triple-negative …

Ubiquitination is a critical type of post-translational modifications, of which K63-linked
ubiquitination regulates interaction, translocation, and activation of proteins. In recent years …

Deubiquitination plays an important role in the regulation of the crosstalk between
macroautophagy/autophagy and innate immune signaling, yet its regulatory mechanisms …

Breast cancer (BC) is a kind of malignant cancer in women, and it has become the most
diagnosed cancer worldwide since 2020. Histone methylation is a common biological …

Tumor metastasis is the main reason for cancer-related death, but there is still a lack of
effective therapeutic to inhibit tumor metastasis. Therefore, the discovery and study of new …

Background CCN6 is a matricellular protein that critically regulates the tumourigenesis and
progression of breast cancer. Although the tumour‐suppressive function of CCN6 has been …

The poor prognosis of serous ovarian cancer (SOC) is due to its high invasive capacity and
cisplatin resistance of SOC cells, whereas the molecular mechanisms remain poorly …