[HTML][HTML] Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior
Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
Calibration of ionic and cellular cardiac electrophysiology models
Cardiac electrophysiology models are among the most mature and well‐studied
mathematical models of biological systems. This maturity is bringing new challenges as …
mathematical models of biological systems. This maturity is bringing new challenges as …
Predicting atrial fibrillation recurrence by combining population data and virtual cohorts of patient-specific left atrial models
Background: Current ablation therapy for atrial fibrillation is suboptimal, and long-term
response is challenging to predict. Clinical trials identify bedside properties that provide only …
response is challenging to predict. Clinical trials identify bedside properties that provide only …
[HTML][HTML] Variability in cardiac electrophysiology: using experimentally-calibrated populations of models to move beyond the single virtual physiological human …
Physiological variability manifests itself via differences in physiological function between
individuals of the same species, and has crucial implications in disease progression and …
individuals of the same species, and has crucial implications in disease progression and …
Pro‐arrhythmogenic effects of atrial fibrillation‐induced electrical remodelling: insights from the three‐dimensional virtual human atria
Key points• Previous studies have shown that atrial electrical properties are altered
(remodelled) by atrial fibrillation (AF) and that the recurrence of AF is high following …
(remodelled) by atrial fibrillation (AF) and that the recurrence of AF is high following …
A detailed mathematical model of the human atrial cardiomyocyte: integration of electrophysiology and cardiomechanics
Mechano‐electric regulations (MER) play an important role in the maintenance of cardiac
performance. Mechano‐calcium and mechano‐electric feedback (MCF and MEF) pathways …
performance. Mechano‐calcium and mechano‐electric feedback (MCF and MEF) pathways …
Inter-subject variability in human atrial action potential in sinus rhythm versus chronic atrial fibrillation
C Sánchez, A Bueno-Orovio, E Wettwer, S Loose… - PloS one, 2014 - journals.plos.org
Aims Human atrial electrophysiology exhibits high inter-subject variability in both sinus
rhythm (SR) and chronic atrial fibrillation (cAF) patients. Variability is however rarely …
rhythm (SR) and chronic atrial fibrillation (cAF) patients. Variability is however rarely …
Cell-specific cardiac electrophysiology models
W Groenendaal, FA Ortega… - PLoS computational …, 2015 - journals.plos.org
The traditional cardiac model-building paradigm involves constructing a composite model
using data collected from many cells. Equations are derived for each relevant cellular …
using data collected from many cells. Equations are derived for each relevant cellular …
Detailed anatomical and electrophysiological models of human atria and torso for the simulation of atrial activation
A Ferrer, R Sebastián, D Sánchez-Quintana… - PloS one, 2015 - journals.plos.org
Atrial arrhythmias, and specifically atrial fibrillation (AF), induce rapid and irregular activation
patterns that appear on the torso surface as abnormal P-waves in electrocardiograms and …
patterns that appear on the torso surface as abnormal P-waves in electrocardiograms and …
Mathematical approaches to understanding and imaging atrial fibrillation: significance for mechanisms and management
NA Trayanova - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common sustained arrhythmia in humans. The mechanisms
that govern AF initiation and persistence are highly complex, of dynamic nature, and involve …
that govern AF initiation and persistence are highly complex, of dynamic nature, and involve …