VEGFA and tumour angiogenesis
L Claesson‐Welsh, M Welsh - Journal of internal medicine, 2013 - Wiley Online Library
In this review we summarize the current understanding of signal transduction downstream of
vascular endothelial growth factor A (VEGFA) and its receptor VEGFR 2, and the relationship …
vascular endothelial growth factor A (VEGFA) and its receptor VEGFR 2, and the relationship …
[HTML][HTML] Rho GTPase signalling in cell migration
AJ Ridley - Current opinion in cell biology, 2015 - Elsevier
Cells migrate in multiple different ways depending on their environment, which includes the
extracellular matrix composition, interactions with other cells, and chemical stimuli. For all …
extracellular matrix composition, interactions with other cells, and chemical stimuli. For all …
Use of the mouse aortic ring assay to study angiogenesis
M Baker, SD Robinson, T Lechertier, PR Barber… - Nature protocols, 2012 - nature.com
Here we provide a protocol for quantitative three-dimensional ex vivo mouse aortic ring
angiogenesis assays, in which developing microvessels undergo many key features of …
angiogenesis assays, in which developing microvessels undergo many key features of …
RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis
HK Bid, RD Roberts, PK Manchanda… - Molecular cancer …, 2013 - AACR
Angiogenesis and metastasis are well recognized as processes fundamental to the
development of malignancy. Both processes involve the coordination of multiple cellular and …
development of malignancy. Both processes involve the coordination of multiple cellular and …
Approaches of targeting Rho GTPases in cancer drug discovery
Y Lin, Y Zheng - Expert opinion on drug discovery, 2015 - Taylor & Francis
Introduction: Rho GTPases are master regulators of actomyosin structure and dynamics and
play pivotal roles in a variety of cellular processes including cell morphology, gene …
play pivotal roles in a variety of cellular processes including cell morphology, gene …
The VEGF/Rho GTPase signalling pathway: a promising target for anti-angiogenic/anti-invasion therapy
R van der Meel, MH Symons, R Kudernatsch… - Drug discovery today, 2011 - Elsevier
It has become increasingly apparent that current antiangiogenic therapy elicits modest
effects in clinical settings. In addition, it remains challenging to treat cancer metastasis …
effects in clinical settings. In addition, it remains challenging to treat cancer metastasis …
Endocytosis regulates VEGF signalling during angiogenesis
K Gaengel, C Betsholtz - Nature cell biology, 2013 - nature.com
Endocytosis has proved to be a versatile mechanism regulating diverse cellular processes,
ranging from nutrient uptake to intracellular signal transduction. New work reinforces the …
ranging from nutrient uptake to intracellular signal transduction. New work reinforces the …
Acute depletion of endothelial β3-integrin transiently inhibits tumor growth and angiogenesis in mice
V Steri, TS Ellison, AM Gontarczyk… - Circulation …, 2014 - Am Heart Assoc
Rationale: The dramatic upregulation of αvβ3-integrin that occurs in the vasculature during
tumor growth has long suggested that the endothelial expression of this molecule is an ideal …
tumor growth has long suggested that the endothelial expression of this molecule is an ideal …
Active Rac1 improves pathologic VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1
MV Hoang, JA Nagy, DR Senger - Blood, The Journal of the …, 2011 - ashpublications.org
Architecturally defective, leaky blood vessels typify pathologic angiogenesis induced by
vascular endothelial growth factor-A (VEGF-A). Such neovascular defects aggravate disease …
vascular endothelial growth factor-A (VEGF-A). Such neovascular defects aggravate disease …
The β3‐integrin endothelial adhesome regulates microtubule‐dependent cell migration
SJ Atkinson, AM Gontarczyk, AAA Alghamdi… - EMBO …, 2018 - embopress.org
Integrin β3 is seen as a key anti‐angiogenic target for cancer treatment due to its expression
on neovasculature, but the role it plays in the process is complex; whether it is pro‐or anti …
on neovasculature, but the role it plays in the process is complex; whether it is pro‐or anti …