In this review we summarize the current understanding of signal transduction downstream of
vascular endothelial growth factor A (VEGFA) and its receptor VEGFR 2, and the relationship …

Cells migrate in multiple different ways depending on their environment, which includes the
extracellular matrix composition, interactions with other cells, and chemical stimuli. For all …

Here we provide a protocol for quantitative three-dimensional ex vivo mouse aortic ring
angiogenesis assays, in which developing microvessels undergo many key features of …

Angiogenesis and metastasis are well recognized as processes fundamental to the
development of malignancy. Both processes involve the coordination of multiple cellular and …

Introduction: Rho GTPases are master regulators of actomyosin structure and dynamics and
play pivotal roles in a variety of cellular processes including cell morphology, gene …

It has become increasingly apparent that current antiangiogenic therapy elicits modest
effects in clinical settings. In addition, it remains challenging to treat cancer metastasis …

Endocytosis has proved to be a versatile mechanism regulating diverse cellular processes,
ranging from nutrient uptake to intracellular signal transduction. New work reinforces the …

Rationale: The dramatic upregulation of αvβ3-integrin that occurs in the vasculature during
tumor growth has long suggested that the endothelial expression of this molecule is an ideal …

Architecturally defective, leaky blood vessels typify pathologic angiogenesis induced by
vascular endothelial growth factor-A (VEGF-A). Such neovascular defects aggravate disease …

Integrin β3 is seen as a key anti‐angiogenic target for cancer treatment due to its expression
on neovasculature, but the role it plays in the process is complex; whether it is pro‐or anti …