Influenza virus contains a single-stranded negative-sense RNA genome. Replication of the
genome is carried out by the viral RNA-dependent RNA polymerase in the context of the …

Bunyaviruses are negative sense, single-strand RNA viruses that infect a wide range of
vertebrate, invertebrate and plant hosts. WHO lists three bunyavirus diseases as priority …

Genetically diverse influenza A viruses (IAVs) circulate in wild aquatic birds. From this
reservoir, IAVs sporadically cause outbreaks, epidemics, and pandemics in wild and …

The current model is that the influenza virus polymerase (FluPol) binds either to host RNA
polymerase II (RNAP II) or to the acidic nuclear phosphoprotein 32 (ANP32), which drives its …

Replication of influenza viral RNA depends on at least two viral polymerases, a parental
replicase and an encapsidase, and cellular factor ANP32. ANP32 comprises an LRR …

During influenza A virus (IAV) infections, viral proteins are targeted by cellular E3 ligases for
modification with ubiquitin. Here, we decipher and functionally explore the ubiquitination …

ABSTRACT DEAD-box helicase 5 (DDX5), a member of the DEAD/H-box helicases, is
known to participate in all aspects of RNA metabolism. However, its regulatory effect in …

Infection with influenza A and B viruses results in a mild to severe respiratory tract infection.
It is widely accepted that many factors affect the severity of influenza disease, including viral …

During annual influenza epidemics, influenza B viruses (IBVs) co-circulate with influenza A
viruses (IAVs), can become predominant and cause severe morbidity and mortality …

Influenza viruses (IV) are single-stranded RNA viruses with a negative-sense genome and
have the potential to cause pandemics. While vaccines exist for influenza, their protection is …