Lipid and immune pathways are crucial in the pathophysiology of metabolic and
cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to …

Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding
hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid …

The view of atherosclerosis as an inflammatory disease has emerged from observations of
immune activation and inflammatory signalling in human atherosclerotic lesions, from the …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

In the vasculature, reactive oxidant species, including reactive oxygen, nitrogen, or
halogenating species, and thiyl, tyrosyl, or protein radicals may oxidatively modify lipids and …

Leukotrienes have physiological roles in innate immune responses and pathological roles in
inflammatory diseases, such as asthma, allergic rhinitis and atherosclerosis. Anti-leukotriene …

Abstract Leukotrienes (LTs) derived from 5-lipoxygenase (5-LO) activity are most widely
known for their actions during acute inflammation and asthma. 5-LO/LT pathway …

Murine atherosclerosis models are highly valuable for identifying atherogenic mechanisms
that can be targeted by preventive medicine. However, models with thrombotic …

Common inflammatome gene signatures as well as disease‐specific signatures were
identified by analyzing 12 expression profiling data sets derived from 9 different tissues …

Macrophages are central to the initiation and progression of atherosclerosis and thus can be
very appropriate targets for therapy. Cell adhesion molecules mediating monocytes …