Abstract Background and Aim: Animal venoms comprise a mix of bioactive molecules with
high affinity for multiple targets in cells and tissues. Scorpion and spider venoms and …

Molecules from animal venoms are promising candidates for the development of new drugs.
Previous in vitro studies have shown that the venom of the spider Phoneutria nigriventer …

The mechanisms of cancer involve changes in multiple biological pathways. Multitarget
molecules, which are components of animal venoms, are therefore a potential strategy for …

Background: Spider venoms induce different physio-pharmacological effects by binding with
high affinity on molecular targets, therefore being of biotechnological interest. Some of these …

Abstract Bites from genus Phoneutria (Ctenidae, Araneomorpha) are the second most
frequent source of spider accidents in Southeast Brazil. Severe envenoming from …

Accidents involving venomous animals are a significant public health problem, since bites
can be lethal or induce clinical complications. Spider bites from the genus Phoneutria …

Background: Spider venom is a potential source of pharmacologically important compounds.
Previous studies on spider venoms reported the presence of bioactive molecules that …

Background Glioblastoma (GB) cells have the ability to migrate and infiltrate the normal
parenchyma, leading to the formation of recurrent tumors often adjacent to the surgical …

An important transcellular transport mechanism in the blood-brain barrier (BBB) involves
caveolae, which are specialized delta-shaped domains of the endothelial plasma …

Numerous studies have shown that the venom of Phoneutria nigriventer (PNV) armed-spider
causes excitotoxic signals and blood–brain barrier breakdown (BBBb) in rats. Nitric oxide …