Large-scale neural recordings call for new insights to link brain and behavior

AE Urai, B Doiron, AM Leifer, AK Churchland - Nature neuroscience, 2022 - nature.com
Neuroscientists today can measure activity from more neurons than ever before, and are
facing the challenge of connecting these brain-wide neural recordings to computation and …

What's the buzz? The neuroscience and the treatment of tinnitus

A Henton, T Tzounopoulos - Physiological reviews, 2021 - journals.physiology.org
Tinnitus is a pervasive public health issue that affects∼ 15% of the United States population.
Similar estimates have also been shown on a global scale, with similar prevalence found in …

Cell-type-specific plasticity of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage

M Kumar, G Handy, S Kouvaros, Y Zhao… - Nature …, 2023 - nature.com
Peripheral sensory organ damage leads to compensatory cortical plasticity that is
associated with a remarkable recovery of cortical responses to sound. The precise …

Long-term stability of cortical ensembles

J Pérez-Ortega, T Alejandre-García, R Yuste - Elife, 2021 - elifesciences.org
Neuronal ensembles, coactive groups of neurons found in spontaneous and evoked cortical
activity, are causally related to memories and perception, but it is still unknown how stable or …

Cortical VIP neurons locally control the gain but globally control the coherence of gamma band rhythms

J Veit, G Handy, DP Mossing, B Doiron, H Adesnik - Neuron, 2023 - cell.com
Gamma band synchronization can facilitate local and long-range neural communication. In
the primary visual cortex, visual stimulus properties within a specific location determine local …

[HTML][HTML] Excitation creates a distributed pattern of cortical suppression due to varied recurrent input

JF O'Rawe, Z Zhou, AJ Li, PK LaFosse, HC Goldbach… - Neuron, 2023 - cell.com
Dense local, recurrent connections are a major feature of cortical circuits, yet how they affect
neurons' responses has been unclear, with some studies reporting weak recurrent effects …

A layered microcircuit model of somatosensory cortex with three interneuron types and cell-type-specific short-term plasticity

HJ Jiang, G Qi, R Duarte, D Feldmeyer… - Cerebral …, 2024 - academic.oup.com
Three major types of GABAergic interneurons, parvalbumin-, somatostatin-, and vasoactive
intestinal peptide-expressing (PV, SOM, VIP) cells, play critical but distinct roles in the …

Learning time-invariant representations for individual neurons from population dynamics

L Mi, T Le, T He, E Shlizerman… - Advances in Neural …, 2023 - proceedings.neurips.cc
Neurons can display highly variable dynamics. While such variability presumably supports
the wide range of behaviors generated by the organism, their gene expressions are …

[HTML][HTML] Multidimensional population activity in an electrically coupled inhibitory circuit in the cerebellar cortex

H Gurnani, RA Silver - Neuron, 2021 - cell.com
Inhibitory neurons orchestrate the activity of excitatory neurons and play key roles in circuit
function. Although individual interneurons have been studied extensively, little is known …

The mechanics of correlated variability in segregated cortical excitatory subnetworks

A Negrón, MP Getz, G Handy, B Doiron - Proceedings of the National …, 2024 - pnas.org
Understanding the genesis of shared trial-to-trial variability in neuronal population activity
within the sensory cortex is critical to uncovering the biological basis of information …