History, discovery, and classification of lncRNAs
J Jarroux, A Morillon, M Pinskaya - Long non coding RNA biology, 2017 - Springer
Abstract The RNA World Hypothesis suggests that prebiotic life revolved around RNA
instead of DNA and proteins. Although modern cells have changed significantly in 4 billion …
instead of DNA and proteins. Although modern cells have changed significantly in 4 billion …
The functions and unique features of LncRNAs in cancer development and tumorigenesis
K Taniue, N Akimitsu - International journal of molecular sciences, 2021 - mdpi.com
Over the past decades, research on cancer biology has focused on the involvement of
protein-coding genes in cancer development. Long noncoding RNAs (lncRNAs), which are …
protein-coding genes in cancer development. Long noncoding RNAs (lncRNAs), which are …
Systematic analysis of telomere length and somatic alterations in 31 cancer types
Cancer cells survive cellular crisis through telomere maintenance mechanisms. We report
telomere lengths in 18,430 samples, including tumors and non-neoplastic samples, across …
telomere lengths in 18,430 samples, including tumors and non-neoplastic samples, across …
Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks
The DNA damage response (DDR) preserves genomic integrity. Small non-coding RNAs
termed DDRNAs are generated at DNA double-strand breaks (DSBs) and are critical for …
termed DDRNAs are generated at DNA double-strand breaks (DSBs) and are critical for …
[HTML][HTML] lincRNAs: genomics, evolution, and mechanisms
Long intervening noncoding RNAs (lincRNAs) are transcribed from thousands of loci in
mammalian genomes and might play widespread roles in gene regulation and other cellular …
mammalian genomes and might play widespread roles in gene regulation and other cellular …
Telomere length determines TERRA and R-loop regulation through the cell cycle
M Graf, D Bonetti, A Lockhart, K Serhal, V Kellner… - Cell, 2017 - cell.com
Maintenance of a minimal telomere length is essential to prevent cellular senescence. When
critically short telomeres arise in the absence of telomerase, they can be repaired by …
critically short telomeres arise in the absence of telomerase, they can be repaired by …
RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells
A fraction of cancer cells maintain telomeres through the telomerase-independent,'
Alternative Lengthening of Telomeres'(ALT) pathway. ALT relies on homologous …
Alternative Lengthening of Telomeres'(ALT) pathway. ALT relies on homologous …
DNA-PK as an emerging therapeutic target in cancer
IS Mohiuddin, MH Kang - Frontiers in oncology, 2019 - frontiersin.org
The DNA-dependent protein kinase (DNA-PK) plays an instrumental role in the overall
survival and proliferation of cells. As a member of the phosphatidylinositol 3-kinase-related …
survival and proliferation of cells. As a member of the phosphatidylinositol 3-kinase-related …
Long noncoding RNAs: past, present, and future
JTY Kung, D Colognori, JT Lee - Genetics, 2013 - academic.oup.com
Long noncoding RNAs (lncRNAs) have gained widespread attention in recent years as a
potentially new and crucial layer of biological regulation. lncRNAs of all kinds have been …
potentially new and crucial layer of biological regulation. lncRNAs of all kinds have been …
[HTML][HTML] Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation
We have applied a super-resolution fluorescence imaging method, stochastic optical
reconstruction microscopy (STORM), to visualize the structure of functional telomeres and …
reconstruction microscopy (STORM), to visualize the structure of functional telomeres and …