Coevolutionary sequence analysis has become a commonly used technique for de novo
prediction of the structure and function of proteins, RNA, and protein complexes. We present …

Many mutations in cancer are of unknown functional significance. Standard methods use
statistically significant recurrence of mutations in tumor samples as an indicator of functional …

Proofreading by replicative DNA polymerases is a fundamental mechanism ensuring DNA
replication fidelity. In proofreading, mis-incorporated nucleotides are excised through the …

This review considers current advances in tools to investigate the functional biology of
Giardia, it's coding and non-coding genes, features and cellular and molecular biology. We …

Predicting protein structure is both fascinating and formidable, playing a crucial role in
structure-based drug discovery and unraveling diseases with elusive origins. The Critical …

Background Driven by deep learning, inter-residue contact/distance prediction has been
significantly improved and substantially enhanced ab initio protein structure prediction …

Natural evolution encodes rich information about the structure and function of biomolecules
in the genetic record. Previously, statistical analysis of co-variation patterns in natural protein …

One of the major challenges in atomistic simulations of proteins is efficient sampling of
pathways associated with rare conformational transitions. Recent developments in statistical …

Abstract Background Cytochrome P450 4F3 (CYP4F3) is an ω‐hydroxylase that oxidizes
leukotriene B4 (LTB4), prostaglandins, and fatty acid epoxides. LTB4 is synthesized by …

Pullulanases are well‐known debranching enzymes hydrolyzing α‐1, 6‐glycosidic linkages.
To date, engineering of pullulanase is mainly focused on catalytic pocket or domain tailoring …