Multi-wavelength analytical ultracentrifugation (MW-AUC) is a recent development made
possible by new analytical ultracentrifuge optical systems. MW-AUC extends the basic …

Analytical ultracentrifugation (AUC) is a critical analytical tool supporting the development
and manufacture of protein therapeutics. AUC is routinely used as an assay orthogonal to …

Gene therapy has entered a new era where numerous therapies for severe and rare
diseases are generating robust and compelling clinical results. The rapid improvements in …

The recent surge of therapeutic interest in recombinant adeno-associated viral (AAV) vectors
for targeted DNA delivery has brought analytical ultracentrifugation (AUC) into the spotlight …

Adeno-associated viruses (AAVs) are non-enveloped, single-stranded DNA viruses that
have recently emerged as an attractive vector for delivering genetic materials to hosts for …

The analytical ultracentrifuge (AUC) and the modern field of analytical ultracentrifugation
found its inception approximately a century ago. We highlight the scope of its major …

DNA in cells is organized in negatively supercoiled loops. The resulting torsional and
bending strain allows DNA to adopt a surprisingly wide variety of 3-D shapes. This interplay …

Sedimentation velocity analytical ultracentrifugation (SV-AUC) is an indispensable tool for
the study of particle size distributions in biopharmaceutical industry, for example, to …

Analytical band centrifugation (ABC) was first developed for the separation of
macromolecules in centrifugation cells~ 60 years ago. Since its development, ABC has been …

Aim: We present multi-wavelength (MW) analytical ultracentrifugation (AUC) methods
offering superior accuracy for adeno-associated virus characterization and quantification …