The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …

In addition to constituting the genetic material of an organism, DNA is a tracer for the
recognition of foreign pathogens and a trigger of the innate immune system. cGAS functions …

Stimulator of interferon genes (STING) is a receptor in human cells that senses foreign cyclic
dinucleotides that are released during bacterial infection and in endogenous cyclic GMP …

Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …

Stimulator of interferon genes (STING) is an adaptor protein in innate immunity against DNA
viruses or bacteria,,,–. STING-mediated immunity could be exploited in the development of …

Host defense against viral pathogens is an essential function for all living organisms. In cell-
intrinsic innate immunity, dedicated sensor proteins recognize molecular signatures of …

Abstract Cyclic GMP–AMP synthase (cGAS) is a cytosolic DNA sensor that produces the
second messenger cG [2′–5′] pA [3′–5′] p (2′ 3′-cGAMP) and controls activation of …

The DNA sensor cyclic GMP-AMP synthase (cGAS) is important for antiviral and anti-tumor
immunity. cGAS generates cyclic GMP-AMP (cGAMP), a diffusible cyclic dinucleotide that …

Listeria monocytogenes is a food-borne pathogen responsible for a disease called
listeriosis, which is potentially lethal in immunocompromised individuals. This bacterium, first …

Summary Stimulator of Interferon Genes (STING) is a critical component of host innate
immune defense but can contribute to chronic autoimmune or autoinflammatory disease …