Covering: up to 2020 The transcription factor NRF2 is one of the body's major defense
mechanisms, driving transcription of> 300 antioxidant response element (ARE)-regulated …

Nrf2 is a major transcription factor that significantly regulates—directly or indirectly—more
than 2000 genes. While many of these genes are involved in maintaining redox balance …

Diabetic cardiomyopathy (DCM) is considered to be a critical contributor to the development
of heart failure. Empagliflozin (EMPA), a sodium‐glucose cotransporter 2 inhibitor, has been …

Continued oxidative stress can lead to chronic inflammation, which in turn could mediate
most chronic diseases including cancer. Nuclear factor erythroid 2-related factor (Nrf2), a …

Acetaminophen (APAP) overdose accounts for the majority of acute liver failure cases, and
oxidative stress plays a key role in its toxic effects. Esculentoside A (EsA) has anti-oxidant …

Arsenic trioxide (ATO) is an excellent therapy for acute promyelocytic leukemia; however, its
use is limited due to its cardiotoxicity. Crocin (CRO) possesses abundant pharmacological …

Ferulic acid, a bacterial metabolite of anthocyanins, seems likely to be a primary mediator of
the health benefits associated with anthocyanin-rich diets, and has long been employed in …

Oxidative stress is an important pathogenic factor in Alzheimer's disease (AD). Recently,
nuclear factor E2-related factor 2 (Nrf2) has emerged as a master regulator for the …

Manganese (Mn) overexposure produces long-term cognitive deficits and reduces brain-
derived neurotrophic factor (BDNF) in the hippocampus. However, it remains elusive …

Abstract Background Mesenchymal stem cells (MSCs) have a therapeutic effect on diabetic
nephropathy (DN) but the underlying mechanism remains unclear. This study was …