The rectal route can be considered a good alternative to the oral route for the paediatric
population because these dosage forms are neither to be swallowed nor need to be taste …

Introduction The effectiveness of valproate (VPA) in the treatment of focal and generalized
epilepsies is well established. The drug has a wide spectrum of action, good tolerability, and …

IV valproate may be given to patients requiring rapid elevation of serum valproate or for
patients unable to take oral medication. Previously we established the loading dose of IV …

Treatment options for epilepsy, especially using antiepileptic drugs, have increased
substantially in the past five years. Since 1993, four novel antiepileptic drugs have been …

Background Status epilepticus (SE) is a serious neurological condition and requires prompt
treatment. Sodium valproate has been used to treat SE successfully but its role as the first …

Background: Status epilepticus (SE) is a type of persistent lasting seizure with high mortality
and morbidity. Numerous medications are suggested for the treatment of SE, two of which …

Few data exist on the management of seizures in brain tumor patients near the end of life.
This article provides information on the epidemiology and phenomenology of seizures, as …

Parenteral antiepileptic drugs (AEDs) are required in patients needing emergent treatment
or unable to take oral medication. In the two United States trials of IV valproate, only low …

A number of antiepileptic drugs (AEDs) can be given rectally for either acute seizure control
or maintenance therapy. In particular, rectal AED therapy may enable physicians who are …

The advent of numerous new treatment options in epilepsy therapy over the last decade is
enabling a more flexible and individualised approach to patients with seizures. For some …