Byproducts of normal mitochondrial metabolism and homeostasis include the buildup of
potentially damaging levels of reactive oxygen species (ROS), Ca2+, etc., which must be …

• Introduction• Mitochondria and cell death• Mitochondrial outer membrane permeabilization
(MOMP): point of no return‐MOMP by BCL‐2 family proteins‐MOMP by permeability …

Poly (ADP-ribose) polymerase-1 (PARP-1), when activated by DNA damage, promotes both
cell death and inflammation. Here we report that PARP-1 enzymatic activity is directly …

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by loss of
dopaminergic neurons and localized neuroinflammation occurring in the midbrain several …

The bidirectional interaction between the gut microbiota (GM) and the Central Nervous
System, the so-called gut microbiota brain axis (GMBA), deeply affects brain function and …

Minocycline is a second-generation, semi-synthetic tetracycline that has been in use in
therapy for over 30 years for its antibiotic properties against both Gram-positive and Gram …

Multiple genetic, metabolic, and environmental abnormalities are known to contribute to the
pathogenesis of Alzheimer's dementia (AD). If all of those abnormalities were addressed it …

Neurodegeneration with brain iron accumulation (NBIA) is a clinically and genetically
heterogeneous group of neurodegenerative diseases characterized by the abnormal …

The mechanism of the neuroprotective action of the tetracycline antibiotic minocycline
against various neuron insults is controversial. In an attempt to clarify this mechanism, we …

Minocycline, an antibiotic of the tetracycline family, has attracted considerable interest for its
theoretical therapeutic applications in neurodegenerative diseases. However, the …