Deep brain stimulation: current challenges and future directions
The clinical use of deep brain stimulation (DBS) is among the most important advances in
the clinical neurosciences in the past two decades. As a surgical tool, DBS can directly …
the clinical neurosciences in the past two decades. As a surgical tool, DBS can directly …
The highs and lows of beta activity in cortico‐basal ganglia loops
Oscillatory activity in the beta (13–30 H z) frequency band is widespread in cortico‐basal
ganglia circuits, and becomes prominent in Parkinson's disease (PD). Here we develop the …
ganglia circuits, and becomes prominent in Parkinson's disease (PD). Here we develop the …
Stimulating at the right time: phase-specific deep brain stimulation
Abstract See Moll and Engel (doi: 10.1093/aww308) for a scientific commentary on this
article. Brain regions dynamically engage and disengage with one another to execute …
article. Brain regions dynamically engage and disengage with one another to execute …
Optimized temporal pattern of brain stimulation designed by computational evolution
Brain stimulation is a promising therapy for several neurological disorders, including
Parkinson's disease. Stimulation parameters are selected empirically and are limited to the …
Parkinson's disease. Stimulation parameters are selected empirically and are limited to the …
Basal ganglia activity patterns in parkinsonism and computational modeling of their downstream effects
The availability of suitable animal models and the opportunity to record electrophysiologic
data in movement disorder patients undergoing neurosurgical procedures has allowed …
data in movement disorder patients undergoing neurosurgical procedures has allowed …
Does suppression of oscillatory synchronisation mediate some of the therapeutic effects of DBS in patients with Parkinson's disease?
There is growing evidence for exaggerated oscillatory neuronal synchronisation in patients
with Parkinson's disease (PD). In particular, oscillations at around 20 Hz, in the so-called …
with Parkinson's disease (PD). In particular, oscillations at around 20 Hz, in the so-called …
Phase dependent modulation of tremor amplitude in essential tremor through thalamic stimulation
High frequency deep brain stimulation of the thalamus can help ameliorate severe essential
tremor. Here we explore how the efficacy, efficiency and selectivity of thalamic deep brain …
tremor. Here we explore how the efficacy, efficiency and selectivity of thalamic deep brain …
Decoupling neuronal oscillations during subthalamic nucleus stimulation in the parkinsonian primate
Subthalamic nucleus (STN) stimulation is a popular treatment for Parkinson's disease;
however, its effect on neuronal activity is unclear. We performed simultaneous multi …
however, its effect on neuronal activity is unclear. We performed simultaneous multi …
Using a hybrid neuron in physiologically inspired models of the basal ganglia
CM Thibeault, N Srinivasa - Frontiers in computational neuroscience, 2013 - frontiersin.org
Our current understanding of the basal ganglia (BG) has facilitated the creation of
computational models that have contributed novel theories, explored new functional …
computational models that have contributed novel theories, explored new functional …
Multi-site stimulation of subthalamic nucleus diminishes thalamocortical relay errors in a biophysical network model
Y Guo, JE Rubin - Neural Networks, 2011 - Elsevier
This paper presents results on a computational study of how multi-site stimulation of the
subthalamic nucleus (STN), within the basal ganglia, can improve the fidelity of …
subthalamic nucleus (STN), within the basal ganglia, can improve the fidelity of …