Since the beginning of the COVID-19 pandemic, extensive drug repurposing efforts have
sought to identify small-molecule antivirals with various mechanisms of action. Here, we aim …

Staphylococcus aureus is a Gram-positive opportunistic human pathogen responsible for
severe infections and thousands of deaths annually, mostly due to its multidrug-resistant …

The COVID-19 pandemic has made it clear that there is a crucial need for the design and
development of antiviral agents that can efficiently reduce the fatality rate caused by …

The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has become an urgent public health problem. Spike (S) protein mediates the fusion between …

Asymptomatically presenting COVID-19 complicates the detection of infected individuals.
Additionally, the virus changes too many genomic variants, which increases the virus's …

Fusion is a key event for enveloped viruses, through which viral and cell membranes come
into close contact. This event is mediated by viral fusion proteins, which are divided into …

Aim The high incidence of virus-related infections and the large diffusion of drug-resistant
pathogens stimulate the search and identification of new antiviral agents with a broad …

Clofazimine and Arbidol have both been reported to be effective in vitro SARS-CoV-2 fusion
inhibitors. Both are promising drugs that have been repurposed for the treatment of COVID …

The ongoing COVID-19 pandemic, caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is partly under control by vaccination. However, highly potent …

Identifying and designing novel antiviral agents are indispensable affairs in biomedicine.
Hesperidin is a flavonoid that is commonly present as a secondary metabolite of citrus fruits …