Research Progress on Spike-Dependent SARS-CoV-2 Fusion Inhibitors and Small Molecules Targeting the S2 Subunit of Spike
MR Freidel, RS Armen - Viruses, 2024 - mdpi.com
Since the beginning of the COVID-19 pandemic, extensive drug repurposing efforts have
sought to identify small-molecule antivirals with various mechanisms of action. Here, we aim …
sought to identify small-molecule antivirals with various mechanisms of action. Here, we aim …
Evaluation of Antimicrobial Properties and Potential Applications of Pseudomonas gessardii M15 Rhamnolipids towards Multiresistant Staphylococcus aureus
Staphylococcus aureus is a Gram-positive opportunistic human pathogen responsible for
severe infections and thousands of deaths annually, mostly due to its multidrug-resistant …
severe infections and thousands of deaths annually, mostly due to its multidrug-resistant …
Antiviral Peptides Delivered by Chitosan-Based Nanoparticles to Neutralize SARS-CoV-2 and HCoV-OC43
The COVID-19 pandemic has made it clear that there is a crucial need for the design and
development of antiviral agents that can efficiently reduce the fatality rate caused by …
development of antiviral agents that can efficiently reduce the fatality rate caused by …
Identification of potential lead compounds targeting novel druggable cavity of SARS-CoV-2 spike trimer by molecular dynamics simulations
Y Zhao, Y Zhao, L Xie, Q Li, Y Zhang, Y Zang… - International Journal of …, 2023 - mdpi.com
The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has become an urgent public health problem. Spike (S) protein mediates the fusion between …
has become an urgent public health problem. Spike (S) protein mediates the fusion between …
Diagnosis of COVID-19 from blood parameters using convolutional neural network
G Erol Doğan, B Uzbaş - Soft Computing, 2023 - Springer
Asymptomatically presenting COVID-19 complicates the detection of infected individuals.
Additionally, the virus changes too many genomic variants, which increases the virus's …
Additionally, the virus changes too many genomic variants, which increases the virus's …
SARS-CoV-2 Fusion Peptide Conjugated to a Tetravalent Dendrimer Selectively Inhibits Viral Infection
Fusion is a key event for enveloped viruses, through which viral and cell membranes come
into close contact. This event is mediated by viral fusion proteins, which are divided into …
into close contact. This event is mediated by viral fusion proteins, which are divided into …
The antiherpetic and anti-inflammatory activity of the frog-derived peptide Hylin-a1
A Chianese, R Giugliano, F Palma… - Journal of Applied …, 2024 - academic.oup.com
Aim The high incidence of virus-related infections and the large diffusion of drug-resistant
pathogens stimulate the search and identification of new antiviral agents with a broad …
pathogens stimulate the search and identification of new antiviral agents with a broad …
The Dual-Targeted Fusion Inhibitor Clofazimine Binds to the S2 Segment of the SARS-CoV-2 Spike Protein
MR Freidel, PA Vakhariya, SK Sardarni, RS Armen - Viruses, 2024 - mdpi.com
Clofazimine and Arbidol have both been reported to be effective in vitro SARS-CoV-2 fusion
inhibitors. Both are promising drugs that have been repurposed for the treatment of COVID …
inhibitors. Both are promising drugs that have been repurposed for the treatment of COVID …
Identification of Z-Tyr-Ala-CHN2, a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2
J Doijen, K Temmerman, C Van den Eynde, A Diels… - Microorganisms, 2023 - mdpi.com
The ongoing COVID-19 pandemic, caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is partly under control by vaccination. However, highly potent …
coronavirus 2 (SARS-CoV-2), is partly under control by vaccination. However, highly potent …
Docking of the main protein receptors of SARS-CoV-2 by hesperidin metabolite: In silico study
Q Hassan Aubais-aljelehawy - Micro Nano Bio Aspects, 2023 - mnba-journal.com
Identifying and designing novel antiviral agents are indispensable affairs in biomedicine.
Hesperidin is a flavonoid that is commonly present as a secondary metabolite of citrus fruits …
Hesperidin is a flavonoid that is commonly present as a secondary metabolite of citrus fruits …