Alzheimer's disease (AD) is conceptualized as a progressive consequence of two hallmark
pathological changes in grey matter: extracellular amyloid plaques and neurofibrillary …

Ferroptosis is a recently identified, iron-regulated, non-apoptotic form of cell death. It is
characterized by cellular accumulation of lipid reactive oxygen species that ultimately leads …

Ferroptosis is form of regulated nonapoptotic cell death that is involved in diverse disease
contexts. Small molecules that inhibit glutathione peroxidase 4 (GPX4), a phospholipid …

Ferroptosis is a regulated form of cell death driven by loss of activity of the lipid repair
enzyme glutathione peroxidase 4 (GPX4) and subsequent accumulation of lipid-based …

The blood coagulation protein fibrinogen is deposited in the brain in a wide range of
neurological diseases and traumatic injuries with blood–brain barrier (BBB) disruption …

Significance: Iron-dependent lipid peroxidation is a complex oxidative process where
phospholipid hydroperoxides (PLOOH) are produced in membranes and finally transformed …

Oligodendrocyte precursor cells (OPCs) account for 5% of the resident parenchymal central
nervous system glial cells. OPCs are not only a back-up for the loss of oligodendrocytes that …

The human preterm brain is particularly susceptible to cerebral white matter injury (WMI) that
disrupts the normal progression of developmental myelination. Advances in the care of …

Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

Oligodendrocyte precursor cells (OPCs) are not merely a transitory progenitor cell type, but
rather a distinct and heterogeneous population of glia with various functions in the …