Although first identified over 70 years ago, Klinefelter syndrome (KS) continues to pose
substantial diagnostic challenges, as many patients are still misdiagnosed, or remain …

Infertility is a widespread problem and a male contribution is involved in 20–70% of affected
couples. As a man's fertility relies on the quantity and quality of his sperm, semen analysis is …

Abstract Background Knowledge about Klinefelter syndrome (KS) has increased
substantially since its first description almost 80 years ago. A variety of treatment options …

BACKGROUND Specific factors underlying successful surgical sperm retrieval rates (SRR)
or pregnancy rates (PR) after testicular sperm extraction (TESE) in adult patients with …

An accurate medical history and directed physical examination are essential in diagnosis of
male infertility. We review the hormonal assessments and specific genetic analyses that are …

STUDY QUESTION Should fertility preservation be offered to children with Klinefelter
syndrome (KS)? SUMMARY ANSWER Current evidence shows that fertility preservation …

Intracytoplasmic sperm injection (ICSI), combined with surgical sperm retrieval (SR)
techniques, is the sole option for patients with non-obstructive azoospermia to achieve …

Introduction: Male infertility affects about 7% of the general male population, and it is a
multifactorial, polygenic pathological condition. Known genetic factors, accounting for about …

STUDY QUESTION When does germ cell loss and fibrosis occur in patients with Klinefelter
syndrome (KS)? SUMMARY ANSWER In KS, germ cell loss is not observed in testicular …

Objective To investigate fertility outcome in individuals with different forms of disorders of sex
development (DSD), if assisted reproductive technology (ART) was used, and the patients' …