MYC is deregulated in most tumour types, but an effective means to selectively target its
aberrant expression is not yet available. Supercoiling that is induced by transcription has …

The unwinding of the parental DNA duplex during replication causes a positive linking
number difference, or superhelical strain, to build up around the elongating replication fork …

The chromatin fiber folds into loops, but the mechanisms controlling loop extrusion are still
poorly understood. Using super-resolution microscopy, we visualize that loops in intact …

DNA as the genetic material is a topic of intense interest in the 21st century, with the
genomes of many organisms having been sequenced. The double helix structure …

By regulating access to the genetic code, DNA supercoiling strongly affects DNA
metabolism. Despite its importance, however, much about supercoiled DNA (positively …

Transcription has the capacity to mechanically modify DNA topology, DNA structure and
nucleosome arrangement. Resulting from ongoing transcription, these modifications in turn …

Abstract As RNA polymerase II (Pol II) transcribes a gene, it encounters an array of well-
ordered nucleosomes. How it traverses through this array in vivo remains unresolved. One …

Because RNA polymerase is a powerful motor, transmission of transcription-generated
forces might directly alter DNA structure, chromatin or gene activity in mammalian cells. Here …

L1 elements are polyA retrotransposons which inhabit the human genome. Recent work has
defined an endonuclease (L1 EN) encoded by the L1 element required for …

Mice lacking topoisomerase IIβ (TopIIβ) are known to exhibit a perinatal death phenotype. In
the current study, transcription profiles of the brains of wild-type and top2 β knockout mouse …