Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

Stem cells are a population of undifferentiated cells characterized by the ability to
extensively proliferate (self-renewal), usually arise from a single cell (clonal), and …

Cardiac fibrosis remains an important health concern, but the study of fibroblast biology has
been hindered by a lack of effective means for identifying and tracking fibroblasts. Recent …

The field of stem-cell biology has been catapulted forward by the startling development of
reprogramming technology. The ability to restore pluripotency to somatic cells through the …

The discovery of induced pluripotent stem cells (iPSCs) by Shinya Yamanaka in 2006 was
heralded as a major breakthrough of the decade in stem cell research. The ability to …

Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell
populations through ectopic expression of defined factors. It remains unclear whether iPSCs …

Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins: Cell Stem Cell Skip
to Main Content Advertisement Cell Stem Cell This journal offers authors two options (open …

Transgenic expression of just four defined transcription factors (c-Myc, Klf4, Oct4 and Sox2)
is sufficient to reprogram somatic cells to a pluripotent state,,,. The resulting induced …

The generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated
that adult mammalian cells can be reprogrammed to a pluripotent state by the enforced …

Pluripotency is generated naturally during mammalian development through formation of the
epiblast, founder tissue of the embryo proper. Pluripotency can be recreated by somatic cell …