Viral persistence and chronicity in hepatitis C virus infection: role of T-cell apoptosis, senescence and exhaustion
Hepatitis C virus (HCV) represents a challenging global health threat to~ 200 million
infected individuals. Clinical data suggest that only~ 10–15% of acutely HCV-infected …
infected individuals. Clinical data suggest that only~ 10–15% of acutely HCV-infected …
Fine tuning subsets of CD4+ T cells by low-dosage of IL-2 and a new therapeutic strategy for autoimmune diseases
Z Zhao, X Zhang, L Su, L Xu, Y Zheng, J Sun - International …, 2018 - Elsevier
Abstract Although Interleukin-2 (IL-2) was identified almost 40 years ago, only recently low
dosage IL-2 therapy is proved to be an effective approach to treat autoimmune diseases …
dosage IL-2 therapy is proved to be an effective approach to treat autoimmune diseases …
HCV-specific CD4+ T cells of patients with acute and chronic HCV infection display high expression of TIGIT and other co-inhibitory molecules
C Ackermann, M Smits, R Woost, JM Eberhard… - Scientific reports, 2019 - nature.com
The combined regulation of a network of inhibitory and activating T cell receptors may be a
critical step in the development of chronic HCV infection. Ex vivo HCV MHC class I+ II …
critical step in the development of chronic HCV infection. Ex vivo HCV MHC class I+ II …
Soluble Immune checkpoint protein CD27 is a Novel Prognostic Biomarker of Hepatocellular Carcinoma Development in Hepatitis C virus–sustained virological …
Factors affecting the probability of hepatocellular carcinoma (HCC) development even after
sustained virological response (SVR) following anti–hepatitis C virus (HCV) therapy remain …
sustained virological response (SVR) following anti–hepatitis C virus (HCV) therapy remain …
Characterization of T cell immunity in chronic hepatitis B virus-infected mothers with postpartum alanine transaminase flare
M Huang, Y Gao, X Yin, X Zhang, Y Hao, J Hu… - BMC Infectious …, 2021 - Springer
Background Postpartum alanine transaminase (ALT) flares occur frequently in chronic
hepatitis B virus (HBV)-infected mothers with antepartum antiviral therapy (AVT). We aimed …
hepatitis B virus (HBV)-infected mothers with antepartum antiviral therapy (AVT). We aimed …
Blockade of BTLA alone or in combination with PD-1 restores the activation and proliferation of CD8+ T cells during in vitro infection with NCP BVDV
Y Liu, Z Zhao, S Su, Y Li, N Chen, L He, M Dong… - Veterinary …, 2024 - Elsevier
Bovine viral diarrhea virus (BVDV) infection can result in typical peripheral blood
lymphopenia and immune dysfunction. However, the molecular mechanism underlying the …
lymphopenia and immune dysfunction. However, the molecular mechanism underlying the …
Expression analysis of PD‐1 and Tim‐3 immune checkpoint receptors in patients with vitiligo; positive association with disease activity
A Rahimi, H Hossein‐Nataj, Z Hajheydari… - Experimental …, 2019 - Wiley Online Library
The contribution of immune checkpoint receptors in the immunopathogenesis of various
autoimmune diseases has been addressed in previous reports. In this study, the expression …
autoimmune diseases has been addressed in previous reports. In this study, the expression …
Focus on T cell exhaustion: new advances in traditional Chinese medicine in infection and cancer
S Li, L Hao, J Zhang, J Deng, X Hu - Chinese Medicine, 2023 - Springer
In chronic infections and cancers, T lymphocytes (T cells) are exposed to persistent antigen
or inflammatory signals. The condition is often associated with a decline in T-cell function: a …
or inflammatory signals. The condition is often associated with a decline in T-cell function: a …
Comparative expression of pro-inflammatory and apoptotic biosignatures in chronic HBV-infected patients with and without liver cirrhosis
The interplay of immune mediators is paramount to optimal host anti-viral immune
responses, especially against chronic hepatitis B virus (HBV) infection. Here, we …
responses, especially against chronic hepatitis B virus (HBV) infection. Here, we …
Chronic infections: a possible scenario for autophagy and senescence cross-talk
MO Aguilera, LR Delgui, PS Romano, MI Colombo - Cells, 2018 - mdpi.com
Multiple tissues and systems in the organism undergo modifications during aging due to an
accumulation of damaged proteins, lipids, and genetic material. To counteract this process …
accumulation of damaged proteins, lipids, and genetic material. To counteract this process …