Combination antiretroviral therapy (ART) for HIV-1 infection reduces plasma virus levels to
below the limit of detection of clinical assays. However, even with prolonged suppression of …

Pathogenic viruses cause many human, animal, and plant diseases that are associated with
substantial morbidity, mortality and socio-economic impact. Although effective strategies for …

Despite long-term antiretroviral therapy (ART), HIV-1 persists within a reservoir of CD4+ T
cells that contribute to viral rebound if treatment is interrupted. Identifying the cellular …

HIV-1 integration into the host genome favors actively transcribed genes. Prior work
indicated that the nuclear periphery provides the architectural basis for integration site …

Whether CD8+ T lymphocytes control human immunodeficiency virus infection by cytopathic
or non-cytopathic mechanisms is not fully understood. Multiple studies highlighted non …

Autophagy is a ubiquitous mechanism involved in the lysosomal-mediated degradation of
cellular components when they are engulfed in vacuoles called autophagosomes …

Recombinant adeno-associated viruses (rAAVs) are among the most important vectors for in
vivo gene therapies. With the rapid development of gene therapy, current rAAV …

CD32 has been shown to be preferentially expressed in latently HIV-1-infected cells in an in
vitro model of quiescent CD4 T cells. Here we show that stimulation of CD4+ T cells with IL …

Background HIV-1-associated immune activation drives CD4+ T cell depletion and the
development of acquired immunodeficiency syndrome. We aimed to determine the role of …

Alternative splicing plays a key role in the HIV-1 life cycle and is essential to maintain an
equilibrium of mRNAs that encode viral proteins and polyprotein-isoforms. In particular …