Antiviral and possible prophylactic significance of myricetin for COVID-19
PK Agrawal, C Agrawal… - Natural Product …, 2023 - journals.sagepub.com
Myricetin (3, 5, 7, 3′, 4′, 5′-hexahydroxyflavone), a common dietary flavonoid, has been
reported for its roles in improving health due to various pharmacological activities, such as …
reported for its roles in improving health due to various pharmacological activities, such as …
Design, synthesis, and pharmacological evaluation of embelin–aryl/alkyl amine hybrids as orally bioavailable blood–brain barrier permeable multitargeted agents with …
VK Nuthakki, S Choudhary, CN Reddy… - ACS chemical …, 2023 - ACS Publications
The complex and multifaceted nature of Alzheimer's disease has brought about a pressing
demand to develop ligands targeting multiple pathways to combat its outrageous …
demand to develop ligands targeting multiple pathways to combat its outrageous …
Hepatoprotective Effects of Flavonoids against Benzo [a] Pyrene-Induced Oxidative Liver Damage along Its Metabolic Pathways
Benzo [a] pyrene (B [a] P), a highly carcinogenic polycyclic aromatic hydrocarbon primarily
formed during incomplete organic matter combustion, undergoes a series of hepatic …
formed during incomplete organic matter combustion, undergoes a series of hepatic …
Rottlerin renders a selective and highly potent CYP2C8 inhibition to impede EET formation for implication in cancer therapy
CYP2C8 is a crucial CYP isoform responsible for the metabolism of xenobiotics and
endogenous molecules. CYP2C8 converts arachidonic acid to epoxyeicosatrienoic acids …
endogenous molecules. CYP2C8 converts arachidonic acid to epoxyeicosatrienoic acids …
Glabridin plays dual action to intensify anti-metastatic potential of paclitaxel via impeding CYP2C8 in liver and CYP2J2/EETs in tumor of an orthotopic mouse model of …
A Jamwal, J Chand, A Dash, S Bhatt, S Dhiman… - Chemico-Biological …, 2023 - Elsevier
In spite of unprecedented advances in modern cancer therapy, there is still a dearth of
targeted therapy to circumvent triple-negative breast cancer (TNBC). Paclitaxel is the front …
targeted therapy to circumvent triple-negative breast cancer (TNBC). Paclitaxel is the front …
Unraveling the Mechanism of Action of Myricetin in the Inhibition of hUba1∼Ubiquitin Thioester Bond Formation via In Silico Molecular Modeling Techniques
Ubiquitination is a crucial type of protein modification which helps to control substrate
degradation and maintain cell homeostasis. Recent studies suggest that ubiquitination and …
degradation and maintain cell homeostasis. Recent studies suggest that ubiquitination and …
ADME/PK Insights of Crocetin: A Molecule Having an Unusual Chemical Structure with Druglike Features
Crocetin is a promising phyto-based molecule to treat Alzheimer's disease (AD). The
chemical structure of crocetin is incongruent with various standard structural features of CNS …
chemical structure of crocetin is incongruent with various standard structural features of CNS …
Assessment of the CYP1A2 Inhibition-Mediated Drug Interaction Potential for Pinocembrin Using In Silico, In Vitro, and In Vivo Approaches
Pinocembrin, a bioflavonoid, is extensively used in complementary/alternative medicine. It
turns out as a promising candidate against neurodegenerative diseases because of its …
turns out as a promising candidate against neurodegenerative diseases because of its …
Cannabidiol-Based Prodrugs: Synthesis and Bioevaluation
Cannabidiol (CBD 1) is a nonpsychotic cannabinoid-based drug approved by the US FDA
for treating refractory epilepsy, namely, Lennox–Gastaut and Dravet syndrome. However, its …
for treating refractory epilepsy, namely, Lennox–Gastaut and Dravet syndrome. However, its …
Identification of new modulator of DNA repairing pathways based on natural product (±)-peharmaline A
The complex heterogenic environment of tumour mass often leads to drug resistance and
facilitate chemo insensitivity triggering more malignant phenotypes among cancer patients …
facilitate chemo insensitivity triggering more malignant phenotypes among cancer patients …