Adaptations to a hypoxic lifestyle in naked mole-rats
ME Pamenter - Journal of Experimental Biology, 2022 - journals.biologists.com
Hypoxia is one of the strongest environmental drivers of cellular and physiological
adaptation. Although most mammals are largely intolerant of hypoxia, some specialized …
adaptation. Although most mammals are largely intolerant of hypoxia, some specialized …
MicroRNA cues from nature: a roadmap to decipher and combat challenges in human health and disease?
MicroRNAs are small non-coding RNA (18–24 nt long) that fine-tune gene expression at the
post-transcriptional level. With the advent of “multi-omics” analysis and sequencing …
post-transcriptional level. With the advent of “multi-omics” analysis and sequencing …
Epigenetic and post-transcriptional repression support metabolic suppression in chronically hypoxic goldfish
Goldfish enter a hypometabolic state to survive chronic hypoxia. We recently described
tissue-specific contributions of membrane lipid composition remodeling and mitochondrial …
tissue-specific contributions of membrane lipid composition remodeling and mitochondrial …
Naked mole-rats resist the accumulation of hypoxia-induced oxidative damage
H Hadj-Moussa, L Eaton, H Cheng… - … and Physiology Part A …, 2022 - Elsevier
Naked mole-rats are among the few mammals with the ability to endure severe hypoxia.
These unique rodents use metabolic rate depression along with various molecular …
These unique rodents use metabolic rate depression along with various molecular …
MicroRNA-mediated inhibition of AMPK coordinates tissue-specific downregulation of skeletal muscle metabolism in hypoxic naked mole-rats
H Hadj-Moussa, S Chiasson, H Cheng… - Journal of …, 2021 - journals.biologists.com
Naked mole-rats reduce their metabolic requirements to tolerate severe hypoxia. However,
the regulatory mechanisms that underpin this metabolic suppression have yet to be …
the regulatory mechanisms that underpin this metabolic suppression have yet to be …
Comparative time-series multi-omics analyses suggest H1. 2 involvement in anoxic adaptation and cancer resistance
J Du, W Liu, M Li, Z Li, X Li, Y Dai, G Liu, X Wang… - PLoS …, 2024 - journals.plos.org
The naked mole rat (NMR), Heterocephalus glaber, is known as the longest-lived rodent and
is extraordinarily resistant to hypoxia and cancer. Here, both NMR embryonic fibroblasts …
is extraordinarily resistant to hypoxia and cancer. Here, both NMR embryonic fibroblasts …
Extreme physiology extreme tolerance to hypoxia, hypercapnia, and pain in the naked mole-rat
Challenging environmental conditions can drive the evolution of extreme physiological traits.
The naked mole-rat has evolved to survive and thrive in a low oxygen, high carbon dioxide …
The naked mole-rat has evolved to survive and thrive in a low oxygen, high carbon dioxide …
Low cancer incidence in naked mole-rats may be related to their inability to express the warburg effect
P Freire Jorge, ML Goodwin, MH Renes… - Frontiers in …, 2022 - frontiersin.org
Metabolic flexibility in mammals enables stressed tissues to generate additional ATP by
converting large amounts of glucose into lactic acid; however, this process can cause …
converting large amounts of glucose into lactic acid; however, this process can cause …
Small RNA sequencing in hypoxic naked mole‐rat hearts suggests microRNA regulation of RNA‐and translation‐related processes
WA Ingelson‐Filpula, H Cheng, L Eaton… - FEBS …, 2022 - Wiley Online Library
The naked mole‐rat (Heterocephalus glaber) regularly endures intermittent periods of
hypoxia in its burrows, surviving in part due to metabolic rate depression (MRD)—a strategy …
hypoxia in its burrows, surviving in part due to metabolic rate depression (MRD)—a strategy …
Hibernation-Induced microRNA Expression Promotes Signaling Pathways and Cell Cycle Dysregulation in Ictidomys tridecemlineatus Cardiac Tissue
WA Ingelson-Filpula, KB Storey - Metabolites, 2023 - mdpi.com
The thirteen-lined ground squirrel Ictidomys tridecemlineatus is a rodent that lives
throughout the United States and Canada and uses metabolic rate depression to facilitate …
throughout the United States and Canada and uses metabolic rate depression to facilitate …