Hypoxia is one of the strongest environmental drivers of cellular and physiological
adaptation. Although most mammals are largely intolerant of hypoxia, some specialized …

MicroRNAs are small non-coding RNA (18–24 nt long) that fine-tune gene expression at the
post-transcriptional level. With the advent of “multi-omics” analysis and sequencing …

Goldfish enter a hypometabolic state to survive chronic hypoxia. We recently described
tissue-specific contributions of membrane lipid composition remodeling and mitochondrial …

Naked mole-rats are among the few mammals with the ability to endure severe hypoxia.
These unique rodents use metabolic rate depression along with various molecular …

Naked mole-rats reduce their metabolic requirements to tolerate severe hypoxia. However,
the regulatory mechanisms that underpin this metabolic suppression have yet to be …

The naked mole rat (NMR), Heterocephalus glaber, is known as the longest-lived rodent and
is extraordinarily resistant to hypoxia and cancer. Here, both NMR embryonic fibroblasts …

Challenging environmental conditions can drive the evolution of extreme physiological traits.
The naked mole-rat has evolved to survive and thrive in a low oxygen, high carbon dioxide …

Metabolic flexibility in mammals enables stressed tissues to generate additional ATP by
converting large amounts of glucose into lactic acid; however, this process can cause …

The naked mole‐rat (Heterocephalus glaber) regularly endures intermittent periods of
hypoxia in its burrows, surviving in part due to metabolic rate depression (MRD)—a strategy …

The thirteen-lined ground squirrel Ictidomys tridecemlineatus is a rodent that lives
throughout the United States and Canada and uses metabolic rate depression to facilitate …