Normal individuals maintain tolerance to the endogenous bacterial flora residing within their
alimentary tract, a phenomenon mediated by the gastrointestinal lymphoid tissue. Loss of …

Crohn's disease and ulcerative colitis are two idiopathic inflammatory disorders of the GI
tract. Manifestations of disease can be severe and lead to long term therapy with a variety of …

The vertebrate body plan is overall symmetrical but left–right (LR) asymmetric in the shape
and positioning of internal organs. Although several theories have been proposed, the …

The revival of thalidomide began shortly after the drug was withdrawn from the market
because of its teratogenic properties. Therapeutic effects of thalidomide were found …

Immunomodulatory drugs (IMiDs) are orally available small molecules that potently inhibit
tumor necrosis factor-α (TNF-α) production by lipopolysaccharide (LPS)-stimulated human …

Thalidomide was developed in the 1950s as a sedative drug and withdrawn in 1961
because of its teratogenic effects, but has been rediscovered as an immuno-modifying drug …

Herein we describe the synthesis of the first Thalidomide–biotin analogue in order to initiate
investigations into the unknown molecular mode of action of Thalidomide. In this manner we …

Durch umfangreiche klinische und grundlagenwissenschaftliche Untersuchungen konnte
die zentrale Rolle des Tumornekrosefaktors-α für die Pathogenese chronisch entzündlicher …

Thalidomide is an effective agent to treat over 25 seemingly unrelated dermatological
conditions that have an inflammatory or autoimmune basis. The main side‐effects of …

Background Maintenance of remission is a major issue in the management of Crohn's
disease. Thalidomide, a tumour necrosis factor‐alpha (TNF‐α) inhibitor and its analogue …