Herpes simplex virus (HSV) infection, the most prevalent viral infection that typically lasts for
a lifetime, is associated with frequent outbreaks of oral and genital lesions. Oral herpes …

Herpes simplex virus (HSV) infections are among the most common viral infections and
usually last for a lifetime. The virus can potentially be controlled with vaccines since humans …

One of the major pathogenesis mechanisms of SARS-CoV-2 is its potent suppression of
innate immunity, including blocking the production of type I interferons. However, it is …

Primary immunodeficiencies represent naturally occurring experimental models to decipher
human immunobiology. We report a patient with combined immunodeficiency, marked by …

The large majority of lymphocytes belong to the adaptive immune system, which are made
up of B2 B cells and the αβ T cells; these are the effectors in an adaptive immune response …

Herpesviral encephalitis caused by Herpes Simplex Virus 1 (HSV-1) is one of the most
devastating diseases in humans. Patients present with fever, mental status changes or …

Type I NKT cells, also known as Invariant Natural Killer T (iNKT) cells, are a subpopulation of
unconventional, innate-like T (ILT) cells which can proficiently influence downstream …

Alphaherpesviruses cause various diseases and establish life-long latent infections in
humans and animals. These viruses encode multiple viral proteins and miRNAs to evade …

Abstract Cluster of Differentiation 1 (CD1) proteins are widely expressed throughout jawed
vertebrates and present lipid antigens to specific CD1-restricted T lymphocytes. CD1 …

Invariant natural killer (iNKT) cells are among the first innate immune cells to elicit early
protective immunity that controls invading viral pathogens. The role of the iNKT cell subsets …