Pyrazole scaffold: a remarkable tool in the development of anticancer agents
Pyrazole has been the topic of interest for thousands of researchers across the world
because of its wide spectrum pharmacological activities. Various structural modifications of …
because of its wide spectrum pharmacological activities. Various structural modifications of …
[HTML][HTML] Synthetic and biological studies of pyrazolines and related heterocyclic compounds
M Yusuf, P Jain - Arabian Journal of Chemistry, 2014 - Elsevier
This review provides a comprehensive survey relating to the synthesis and biological
applications of pyrazolines and related heterocycles in the last five years (2007–2011) …
applications of pyrazolines and related heterocycles in the last five years (2007–2011) …
Design, synthesis and biological evaluation of 1, 3-diphenyl-1H-pyrazole derivatives containing benzimidazole skeleton as potential anticancer and apoptosis …
A series of forty different pyrazole containing benzimidazole hybrids (6–45) have been
designed, synthesized and evaluated for their potential anti-proliferative activity against …
designed, synthesized and evaluated for their potential anti-proliferative activity against …
Regioselective [3+ 2] cycloaddition synthesis and theoretical calculations of new chromene-pyrazole hybrids: A DFT-based Parr Function, Fukui Function, local …
Abstract The [3+ 2] cycloaddition synthesis of new series of chromene-pyrazole hybrids was
the focus of this research. New chromene-based enaminones were synthesized and used …
the focus of this research. New chromene-based enaminones were synthesized and used …
Synthesis of some new pyrazole-based 1, 3-thiazoles and 1, 3, 4-thiadiazoles as anticancer agents
Abstract N-(4-(Pyrazol-4-yl) thiazol-2-yl)-N′-phenylthiourea derivative 2 was synthesized
and then treated with variety of hydrazonoyl chlorides under basic condition at reflux to …
and then treated with variety of hydrazonoyl chlorides under basic condition at reflux to …
Design, synthesis and molecular modeling of pyrazole–quinoline–pyridine hybrids as a new class of antimicrobial and anticancer agents
CB Sangani, JA Makawana, X Zhang… - European Journal of …, 2014 - Elsevier
A new series of pyrazole–quinoline–pyridine hybrids were designed based on molecular
hybridization technique and synthesized by a base-catalyzed cyclocondensation reaction …
hybridization technique and synthesized by a base-catalyzed cyclocondensation reaction …
Synthesis and antiviral activity of some new bis-1, 3-thiazole derivatives
Abstract Treatment of 3-phenyl-1, 3-thiazolidin-4-one derivative 1 with phenylisothiocyanate
in DMF, in the presence of potassium hydroxide, at room temperature gave the non-isolable …
in DMF, in the presence of potassium hydroxide, at room temperature gave the non-isolable …
A comprehensive review of N-heterocycles as cytotoxic agents
D Kumar, S Kumar Jain - Current Medicinal Chemistry, 2016 - ingentaconnect.com
Scientific community is striving to understand the role of heterocycles and fused
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …
Synthesis and structure–activity relationship of 1-and 2-substituted-1, 2, 3-triazole letrozole-based analogues as aromatase inhibitors
J Doiron, R Richard, MM Touré, N Picot… - European journal of …, 2011 - Elsevier
A series of bis-and mono-benzonitrile or phenyl analogues of letrozole 1, bearing (1, 2, 3
and 1, 2, 5)-triazole or imidazole, were synthesized and screened for their anti-aromatase …
and 1, 2, 5)-triazole or imidazole, were synthesized and screened for their anti-aromatase …
Single step synthesis of new fused pyrimidine derivatives and their evaluation as potent Aurora-A kinase inhibitors
MR Shaaban, TS Saleh, AS Mayhoub… - European Journal of …, 2011 - Elsevier
A simple, facile, efficient and one pot three-component procedure for the synthesis of
pyrazolo [1, 5-a] pyrimidines, triazolo [1, 5-a] pyrimidines and pyrimido [1, 2-a] …
pyrazolo [1, 5-a] pyrimidines, triazolo [1, 5-a] pyrimidines and pyrimido [1, 2-a] …