Manipulating neutrophil degranulation as a bacterial virulence strategy

KR Eichelberger, WE Goldman - PLoS pathogens, 2020 - journals.plos.org
Armed with an arsenal of antimicrobial mechanisms, neutrophils are among the first innate
immune cells recruited to the site of bacterial infection. Neutrophils utilize both oxidative and …

Yersinia interactions with regulated cell death pathways

KW Chen, IE Brodsky - Current Opinion in Microbiology, 2023 - Elsevier
Cell death in response to infection is conserved across all kingdoms of life. In metazoans,
cell death upon bacterial infection is primarily carried out by the cysteine and aspartate …

Type 3 secretion system induced leukotriene B4 synthesis by leukocytes is actively inhibited by Yersinia pestis to evade early immune recognition

A Brady, KR Sheneman, AR Pulsifer, SL Price… - Plos …, 2024 - journals.plos.org
Subverting the host immune response to inhibit inflammation is a key virulence strategy of
Yersinia pestis. The inflammatory cascade is tightly controlled via the sequential action of …

[HTML][HTML] Pan-genomics, drug candidate mining and ADMET profiling of natural product inhibitors screened against Yersinia pseudotuberculosis

Z Basharat, M Jahanzaib, A Yasmin, IA Khan - Genomics, 2021 - Elsevier
Yersinia pseudotuberculosis belongs to the family Enterobacteriaceae and is responsible for
scarlatinoid fever, food poisoning, post-infectious complications like erythema …

Pathogenicity and virulence of Yersinia

JA Seabaugh, DM Anderson - Virulence, 2024 - Taylor & Francis
The genus Yersinia includes human, animal, insect, and plant pathogens as well as many
symbionts and harmless bacteria. Within this genus are Yersinia enterocolitica and the …

Host manipulation by bacterial type III and type IV secretion system effector proteases

F Viana, SS Peringathara, A Rizvi… - Cellular …, 2021 - Wiley Online Library
Proteases are powerful enzymes, which cleave peptide bonds, leading most of the time to
irreversible fragmentation or degradation of their substrates. Therefore they control many …

Redundant and cooperative roles for Yersinia pestis yop effectors in the inhibition of human neutrophil exocytic responses revealed by gain-of-function approach

AR Pulsifer, A Vashishta, SA Reeves… - Infection and …, 2020 - Am Soc Microbiol
Yersinia pestis causes a rapid, lethal disease referred to as plague. Y. pestis actively inhibits
the innate immune system to generate a noninflammatory environment during early stages …

Mapping quantitative trait loci related to nodule number in soybean (Glycine max (L.) Merr.) in response to the Sinorhizobium (Ensifer) fredii HH103 NopT type III …

Y Liu, M Sun, Q Chen, D Xin, X Sun - Journal of Plant Interactions, 2021 - Taylor & Francis
Type III effectors play a vital role in the establishment of symbiosis. In this study, positive and
negative effects of NopT on nodulation were detected in 30 soybean germplasms. The …

Advances and challenges in studying type III secretion effectors of attaching and effacing pathogens

SL Slater, G Frankel - Frontiers in Cellular and Infection Microbiology, 2020 - frontiersin.org
Outbreaks of the diarrhoeal disease caused by enteropathogenic Escherichia coli (EPEC)
and enterohaemorrhagic E. coli (EHEC) present a significant burden to public health in …

[HTML][HTML] Yersinia pestis escapes entrapment in thrombi by targeting platelet function

SG Palace, O Vitseva, MK Proulx, JE Freedman… - Journal of Thrombosis …, 2020 - Elsevier
Background Platelets are classically recognized for their role in hemostasis and thrombosis.
Recent work has demonstrated that platelets can also execute a variety of immune functions …