Research progress in live attenuated Brucella vaccine development

Z Wang, Q Wu - Current Pharmaceutical Biotechnology, 2013 - ingentaconnect.com
Brucella spp. are facultative intracellular bacteria that cause brucellosis, which is a globally
occurring zoonotic disease that is characterized by abortion in domestic animals and …

[HTML][HTML] Current methods of human and animal brucellosis diagnostics

EA Smirnova, AV Vasin, NT Sandybaev, SA Klotchenko… - 2013 - scirp.org
Brucellosis is an urgent infectious disease of livestock and wild animals and the commonest
human zoonosis. Diagnosis of brucellosis is rather complicated and it has to be obligatorily …

A sandwich immunoassay for brucellosis diagnosis based on immune magnetic beads and quantum dots

L Li, D Yin, K Xu, Y Liu, D Song, J Wang, C Zhao… - … of pharmaceutical and …, 2017 - Elsevier
Brucellosis is a serious zoonosis with a rapid increase in incidence across epidemic
regions. Currently, there are numerous methods for diagnosing brucellosis. However, these …

Molecular prevalence of putative virulence-associated genes in Brucella melitensis and Brucella abortus isolates from human and livestock specimens in Iran

I Hashemifar, A Yadegar, FM Jazi… - Microbial pathogenesis, 2017 - Elsevier
Molecular prevalence of nine putative virulence factors in two more prevalent Brucella
species in Iranian patients and livestock was investigated. During five years (2010–2015) …

Brucella melitensis VirB12 recombinant protein is a potential marker for serodiagnosis of human brucellosis

S Mirkalantari, AH Zarnani, M Nazari, GR Irajian… - Annals of Clinical …, 2017 - Springer
Background The numerous drawbacks of current serological tests for diagnosis of
brucellosis which mainly results from cross reactivity with LPS from other gram-negative …

Diagnosis of human and canine Brucella canis infection: development and evaluation of indirect enzyme-linked immunosorbent assays using recombinant Brucella …

MM Sánchez-Jiménez, JJ de la Cuesta Zuluaga… - Heliyon, 2020 - cell.com
Brucella canis, a Gram-negative coccobacilli belonging to the genus Brucellae, is a
pathogenic bacterium that can produce infections in dogs and humans. Multiple studies …

A safe and molecular-tagged Brucella canis ghosts confers protection against virulent challenge in mice

J Qian, Z Bu, X Lang, G Yan, Y Yang, X Wang… - Veterinary …, 2017 - Elsevier
Canine brucellosis, caused by Brucella canis, is a persistent infectious reproductive disease
in dogs. The absence of effective treatment to the intracellular pathogen and the irreversible …

Cytokines production and toll-like receptors expression in human leukemic monocyte cells, THP-1, stimulated with Brucella abortus cellular antigens

YB Im, S Shim, SH Soh, S Kim, HS Yoo - Microbial pathogenesis, 2018 - Elsevier
A zoonotic pathogen, Brucella spp. is the causative agent of brucellosis, which results in
abortion and loss in milk production in domestic animals, and undulant fever, osteoarticular …

Recombinant proteins as antigens in serological diagnosis of brucellosis

M Navarro-Soto, A Morales-Loredo… - Updates on …, 2015 - books.google.com
Brucellosis is considered the major zoonosis in developing countries. In susceptible animal
species, diagnosis of brucellosis remains a challenge due to the variety of clinical signs that …

An evaluation of ELISA using recombinant Brucella abortus bacterioferritin (Bfr) for bovine brucellosis

HT Hop, LT Arayan, HL Simborio, AWB Reyes… - … and Infectious Diseases, 2016 - Elsevier
To date, detection of antibodies against the lipopolysaccharide portion is the backbone of
most serodiagnostic methods for brucellosis screening. However this pose a risk for false …