Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …

The control over the extent and timing of G protein signaling is provided by the regulator of G
protein signaling (RGS) proteins that deactivate G protein α subunits (Gα). Mammalian …

Regulator of G protein signaling (RGS) proteins are responsible for the rapid turnoff of G
protein–coupled receptor signaling pathways. The major mechanism whereby RGS proteins …

G-protein-coupled receptors (GPCRs) are major targets for drug discovery. The regulator of
G-protein signalling (RGS)-protein family has important roles in GPCR signal transduction …

G‐protein regulated inward‐rectifier potassium channels (GIRK) are part of a superfamily of
inward‐rectifier K+ channels which includes seven family members. To date four GIRK …

Regulators of G-protein signalling (RGS proteins) are a family of highly diverse,
multifunctional signalling proteins that share a conserved 120 amino acid domain (RGS …

Regulators of G-protein signalling (RGS) proteins are a large and diverse family initially
identified as GTPase activating proteins (GAPs) of heterotrimeric G-protein Gα-subunits. At …

G protein-coupled receptor signaling pathways mediate the transmission of signals from the
extracellular environment to the generation of cellular responses, a process that is critically …

Regulators of G-protein signaling (RGS) proteins act as GTPase-activating proteins (GAPs)
for α subunits of heterotrimeric G-proteins. Previous in situ hybridization analysis of mRNAs …

Chronic l-dopa treatment of Parkinson's disease (PD) often leads to debilitating involuntary
movements, termed l-dopa-induced dyskinesia (LID), mediated by dopamine (DA) receptors …