The development of targeted medicine has greatly expanded treatment options and spurred
new research avenues in cancer therapeutics, with monoclonal antibodies (mAbs) emerging …

Due to the complex physiological structure, microenvironment and multiple physiological
barriers, traditional anti‐cancer drugs are severely restricted from reaching the tumour site …

As antibody–drug conjugates have become a very important modality for cancer therapy,
many site-specific conjugation approaches have been developed for generating …

Single-domain antibodies derive from the heavy-chain-only antibodies of Camelidae (camel,
dromedary, llama, alpaca, vicuñas, and guananos; ie, nanobodies) and cartilaginous fishes …

The renaissance of peptides as prospective therapeutics has fostered the development of
novel strategies for their synthesis and modification. In this context, besides the development …

Sortases are enzymes occurring in the cell wall of Gram-positive bacteria. Sortase A (SrtA),
the best studied sortase class, plays a key role in anchoring surface proteins with the …

Cell-penetrating peptides (CPPs) have emerged as powerful tools in terms of drug delivery.
Those short, often cationic peptides are characterized by their usually low toxicity and their …

Simple Summary Neuroimaging has transformed the way brain tumors are diagnosed and
treated. Although different non-invasive modalities provide very helpful information, in some …

Highlights•CPPs are valuable tools for the intracellular delivery of anti-cancer
drugs.•Attachment of targeting units to CPPs helps to increase their selectivity.•Self …

Simple Summary Variable domains of heavy chain only antibodies are small proteins that
can be used for tumor imaging and therapy upon conjugation of functional groups. As …