Metals at the Host–Fungal Pathogen Battleground

R Garg, MS David, S Yang… - Annual Review of …, 2024 - annualreviews.org
Fungal infections continue to represent a major threat to public health, particularly with the
emergence of multidrug-resistant fungal pathogens. As part of the innate immune response …

Novel avenues for identification of new antifungal drugs and current challenges

J Jampilek - Expert Opinion on Drug Discovery, 2022 - Taylor & Francis
Introduction Some of the fungi have become pathogenic to humans, and these opportunistic
pathogens are able to cause severe systemic mycoses. Areas covered The number of …

[HTML][HTML] Physiological and transcriptional profiling of surfactin exerted antifungal effect against Candida albicans

Á Jakab, F Kovács, N Balla, Z Tóth, Á Ragyák… - Biomedicine & …, 2022 - Elsevier
Given the risk of Candida albicans overgrowth in the gut, novel complementary therapies
should be developed to reduce fungal dominancy. This study highlights the antifungal …

Calcitermin-Loaded Smart Gels Activity against Candida albicans: A Preliminary In Vitro Study

D Bellotti, M D'accolti, W Pula, N Huang, F Simeliere… - Gels, 2023 - mdpi.com
Calcitermin is an antimicrobial peptide of 15 amino acids found in human nasal fluid
characterized by antifungal and antibacterial properties. Candida albicans is the most …

Zn2+ and Cu2+ Interaction with the Recognition Interface of ACE2 for SARS-CoV-2 Spike Protein

A Pelucelli, M Peana, B Orzeł, K Piasta… - International Journal of …, 2023 - mdpi.com
The spike protein (S) of SARS-CoV-2 is able to bind to the human angiotensin-converting
enzyme 2 (ACE2) receptor with a much higher affinity compared to other coronaviruses. The …

[HTML][HTML] Investigation of metal interactions with YrpE protein of Bacillus subtilis by a polyhistidine peptide model

D Bellotti, S Leveraro, A Hecel, M Remelli - Analytical Biochemistry, 2023 - Elsevier
The use of model peptides that can simulate the behaviour of a protein domain is a very
successful analytical method to study the metal coordination sites in biological systems …

Toxic and essential metals in human health and disease 2021

JO Aaseth - Biomolecules, 2022 - mdpi.com
The Special Issue of Biomolecules called “Toxic and Essential Metals in Human Health and
Disease 2021” represents a follow-up of the previous Special Issue with the name of “Toxic …

Metal coordination governs the antimicrobial efficacy of calcitermin derivatives

S Leveraro, K Garstka, P Śliwka, T Janek… - Dalton …, 2024 - pubs.rsc.org
Antimicrobial peptides are promising alternatives to classical antibiotics. Their microbicidal
activity can arise from different mechanisms, one of which is known as nutritional immunity …

CDF family of zinc transporters ZRC-1, MSC-2, and ZRG-17 are involved in survival at high zinc conditions, vegetative development, and cellulase utilization in …

S Ngiimei D, R Tamuli - Journal of Biosciences, 2024 - Springer
The cation diffusion facilitator (CDF) family of zinc transporters plays a crucial role in zinc
homeostasis in eukaryotes, including fungi. Here, we investigated the cell functions and …

Metal–protein solution interactions investigated using model systems: Thermodynamic and spectroscopic methods

D Bellotti, S Leveraro, M Remelli - Methods in Enzymology, 2023 - Elsevier
The first-row D-block metal ions are essential for the physiology of living organisms,
functioning as cofactors in metalloproteins or structural components for enzymes: almost half …