Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …

Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for
chromosomal pairing and exchange during meiosis. However, some forms of HR can also …

Germline mutations in a number of genes involved in the recombinational repair of DNA
double-strand breaks are associated with predisposition to breast and ovarian cancer …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

Radiation therapy plays an important role in the management of a wide range of cancers.
Besides innovations in the physical application of radiation dose, radiation therapy is likely …

Fanconi anemia (FA) is a rare chromosomal-instability disorder associated with a variety of
developmental abnormalities, bone marrow failure and predisposition to leukemia and other …

Chromosomal double-strand breaks (DSBs) have the potential to permanently arrest cell
cycle progression and endanger cell survival. They must therefore be efficiently repaired to …

The Rad51 paralogs are required for homologous recombination (HR) and the maintenance
of genomic stability. The molecular mechanisms by which the five vertebrate Rad51 …

Sustaining DNA damage response (DDR) signalling via retention of DDR factors at
damaged sites is important for transmitting damage-sensing and repair signals. Herein, we …

A PARP inhibitor is a rationally designed targeted therapy for cancers with impaired DNA
repair abilities. RAD51C is a paralog of RAD51 that has an important role in the DNA …