Ceramides and other sphingolipids as drivers of cardiovascular disease

RH Choi, SM Tatum, JD Symons… - Nature Reviews …, 2021 - nature.com
Increases in calorie consumption and sedentary lifestyles are fuelling a global pandemic of
cardiometabolic diseases, including coronary artery disease, diabetes mellitus …

Pathophysiology and therapeutic approaches to acute decompensated heart failure

JN Njoroge, JR Teerlink - Circulation research, 2021 - Am Heart Assoc
Acute decompensated heart failure (ADHF) is one of the leading admission diagnoses
worldwide, yet it is an entity with incompletely understood pathophysiology and limited …

A wireless patch for the monitoring of C-reactive protein in sweat

J Tu, J Min, Y Song, C Xu, J Li, J Moore… - Nature biomedical …, 2023 - nature.com
The quantification of protein biomarkers in blood at picomolar-level sensitivity requires
labour-intensive incubation and washing steps. Sensing proteins in sweat, which would …

Incidence and epidemiology of new onset heart failure with preserved vs. reduced ejection fraction in a community-based cohort: 11-year follow-up of PREVEND

FP Brouwers, RA de Boer, P van der Harst… - European heart …, 2013 - academic.oup.com
Aims Differences in clinical characteristics and outcome of patients with established heart
failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection …

Large and small animal models of heart failure with reduced ejection fraction

PM Pilz, JE Ward, WT Chang, A Kiss, E Bateh… - Circulation …, 2022 - Am Heart Assoc
Heart failure (HF) describes a heterogenous complex spectrum of pathological conditions
that results in structural and functional remodeling leading to subsequent impairment of …

Pathophysiological basis of the cardiological benefits of SGLT-2 inhibitors: a narrative review

C Panico, B Bonora, A Camera, NC Chilelli… - Cardiovascular …, 2023 - Springer
In recent years, GLP-1 receptor agonists (GLP-1RA), and SGLT-2 inhibitors (SGLT-2i) have
become available, which have become valuable additions to therapy for type 2 diabetes as …

Cardiac lipid metabolism, mitochondrial function, and heart failure

L Da Dalt, AG Cabodevilla, IJ Goldberg… - Cardiovascular …, 2023 - academic.oup.com
A fine balance between uptake, storage, and the use of high energy fuels, like lipids, is
crucial in the homeostasis of different metabolic tissues. Nowhere is this balance more …

Chronic low‐grade inflammation in heart failure with preserved ejection fraction

T Mesquita, YN Lin, A Ibrahim - Aging Cell, 2021 - Wiley Online Library
Heart failure (HF) with preserved ejection fraction (HFpEF) is currently the predominant form
of HF with a dramatic increase in risk with age. Low‐grade inflammation, as occurs with …

[HTML][HTML] Pathophysiology of heart failure

RHG Schwinger - Cardiovascular diagnosis and therapy, 2021 - ncbi.nlm.nih.gov
Heart failure is an epidemic disease which affects about 1% to 2% of the population
worldwide. Both, the etiology and phenotype of heart failure differ largely. Following a …

Mechanisms of benefits of sodium-glucose cotransporter 2 inhibitors in heart failure with preserved ejection fraction

AK Pandey, DL Bhatt, A Pandey, N Marx… - European heart …, 2023 - academic.oup.com
For decades, heart failure with preserved ejection fraction (HFpEF) proved an elusive entity
to treat. Sodium-glucose cotransporter 2 (SGLT2) inhibitors have recently been shown to …