Monogenic diabetes includes several clinical conditions generally characterized by early-
onset diabetes, such as neonatal diabetes, maturity-onset diabetes of the young (MODY) …

Monogenic diabetes refers to diabetes mellitus (DM) caused by a mutation in a single gene
and accounts for approximately 1%–5% of diabetes. Correct diagnosis is clinically critical for …

ISPAD Clinical Practice Consensus Guidelines 2022: The diagnosis and management of
monogenic diabetes in children and adolescents - PMC Back to Top Skip to main content NIH …

Improving glucose sensitivity remains an unmet medical need in treating type 2 diabetes
(T2D). Dorzagliatin is a dual-acting, orally bioavailable glucokinase activator that enhances …

Glucokinase–maturity-onset diabetes of the young (GCK-MODY), also known as MODY2, is
caused by heterozygous inactivating mutations in the GCK gene. GCK gene mutations are …

Penetrance is the probability that an individual with a pathogenic genetic variant develops a
specific disease. Knowing the penetrance of variants for monogenic disorders is important …

Background Monogenic diabetes presents opportunities for precision medicine but is
underdiagnosed. This review systematically assessed the evidence for (1) clinical criteria …

Glucokinase (GCK), a key enzyme in glucose metabolism, plays a central role in glucose
sensing and insulin secretion in pancreatic β-cells, as well as glycogen synthesis in the liver …

Abstract Maturity Onset Diabetes of the Young (MODY) is a monogenic form of diabetes
diagnosed in young individuals that lack the typical features of type 1 and type 2 diabetes …

Amino acid substitutions can perturb protein activity in multiple ways. Understanding their
mechanistic basis may pinpoint how residues contribute to protein function. Here, we …