Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …

Acylated flavonoids are widely distributed natural metabolites in medicinal plants and foods
with several health attributes. A large diversity of chemical structures of acylated flavonoids …

This study aimed to design potent carbonic anhydrase inhibitors (CAIs) based on pyrazole
benzenesulfonamide core. Nine series of substituted pyrazole benzenesulfonamide …

Coumarins are natural products characterized as 2H-chromen-2-one, according to IUPAC
nomenclature, largely distributed in plants, as well as, in species of fungi and bacteria …

Alzheimer disease (AD) is one of the major neurodegenerative diseases that could not be
prevented or completely cured and may lead to death. Here, we target AChE and β-amyloid …

A series of novel carbazole based α-aminophosphonate derivatives were synthesized under
solvent-free condition, characterized and evaluated for their cholinesterase inhibition …

Herein, a series of novel antipyrine based α-aminophosphonates derivatives were
synthesized and characterized. The synthesized derivatives were subjected for in vitro …

Iminophosphoranes are commonly used reagents in organic synthesis and are, therefore, of
great interest. An efficient and sustainable iodide-mediated electrochemical synthesis of N …

Inhibition of acetylcholinesterase has been validated as an effective target for treatment of
Alzheimer's disease by increasing the levels of acetylcholine and improving the …

The primary focus of bisphosphonate medications is on targeting human farnesyl
pyrophosphate synthase (hFPPS), an essential regulator of mammalian isoprenoids. Yet …