Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier
experiments have found that VSMCs possess high plasticity. Vascular injury stimulates …

Multiple layers of vascular smooth muscle cells (vSMCs) are present in blood vessels
forming the media of the vessel wall. vSMCs provide a vessel wall structure, enabling it to …

The pathobiology of atherosclerotic disease requires further elucidation to discover new
approaches to address its high morbidity and mortality. To date, over 17 million …

Foam cells play a vital role in the initiation and development of atherosclerosis. This review
aims to summarize the novel insights into the origins, consequences, and molecular …

Advances in single-cell RNA sequencing (scRNA-seq) technologies in the past 10 years
have had a transformative effect on biomedical research, enabling the profiling and analysis …

Vascular smooth muscle cells (VSMCs) are involved in phenotypic switching in
atherosclerosis. This switching is characterized by VSMC dedifferentiation, migration, and …

Arterial occlusive disease is the leading cause of death in Western countries. Core
contemporary therapies for this disease include angioplasties, stents, endarterectomies and …

Background: Vascular homeostasis is maintained by the differentiated phenotype of
vascular smooth muscle cells (VSMCs). The landscape of protein coding genes comprising …

Background: The metalloprotease ADAMTS-7 (a disintegrin and metalloproteinase with
thrombospondin type 1 motif 7) is a novel locus associated with human coronary …

Brown adipose tissue can expend large amounts of energy, and therefore increasing its size
or activity is a promising therapeutic approach to combat metabolic disease. In humans …