Gastrointestinal epithelial innate immunity—regionalization and organoids as new model
Ö Kayisoglu, N Schlegel, S Bartfeld - Journal of Molecular Medicine, 2021 - Springer
The human gastrointestinal tract is in constant contact with microbial stimuli. Its barriers have
to ensure co-existence with the commensal bacteria, while enabling surveillance of intruding …
to ensure co-existence with the commensal bacteria, while enabling surveillance of intruding …
[HTML][HTML] Patient-derived organoids for therapy personalization in inflammatory bowel diseases
M Lucafò, A Muzzo, M Marcuzzi, L Giorio… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders of the intestinal tract
that have emerged as a growing problem in industrialized countries. Knowledge of IBD …
that have emerged as a growing problem in industrialized countries. Knowledge of IBD …
The involvement of the primo vascular system in local enteritis and its modification by electroacupuncture
S Nan, J Wan, Q Lei, X Wang, N Ma, R Yin… - Frontiers in …, 2023 - frontiersin.org
Introduction The primo vascular system (PVS), an intensive network structure, has been
claimed to be representative of the acupuncture meridian. Here, we explored the role of the …
claimed to be representative of the acupuncture meridian. Here, we explored the role of the …
Chemotherapy-induced intestinal injury promotes Galectin-9-driven modulation of T cell function
SA Jansen, A Cutilli, C de Koning, M van Hoesel… - bioRxiv, 2023 - biorxiv.org
The intestine is vulnerable to chemotherapy-induced toxicity due to its high epithelial
proliferative rate, making gut toxicity an off-target effect in several cancer treatments …
proliferative rate, making gut toxicity an off-target effect in several cancer treatments …
[HTML][HTML] Exploring the potential of human intestinal organoids: Applications, challenges, and future directions
IA Parente, L Chiara, S Bertoni - Life Sciences, 2024 - Elsevier
The complex and dynamic environment of the gastrointestinal tract shapes one of the fastest
renewing tissues in the human body, the intestinal epithelium. Considering the lack of …
renewing tissues in the human body, the intestinal epithelium. Considering the lack of …
Chemotherapy-induced intestinal epithelial damage directly promotes galectin-9-driven modulation of T cell behavior
SA Jansen, A Cutilli, C de Koning, M van Hoesel… - iScience, 2024 - cell.com
The intestine is vulnerable to chemotherapy-induced damage due to the high rate of
intestinal epithelial cell (IEC) proliferation. We have developed a human intestinal organoid …
intestinal epithelial cell (IEC) proliferation. We have developed a human intestinal organoid …
[HTML][HTML] Patient-derived colonoids from disease-spared tissue retain inflammatory bowel disease-specific transcriptomic signatures
TA Karakasheva, Y Zhou, HM Xie, GE Soto… - Gastro hep …, 2023 - Elsevier
Background and Aims A key histopathological feature of inflammatory bowel disease is
damage to the mucosa, including breakdown of the epithelial barrier. Human enteroids and …
damage to the mucosa, including breakdown of the epithelial barrier. Human enteroids and …
Characterization of patient-derived intestinal organoids for modelling fibrosis in Inflammatory Bowel Disease
I Laudadio, C Carissimi, N Scafa, A Bastianelli… - Inflammation …, 2024 - Springer
Background and aims Intestinal fibrosis is a common complication of Inflammatory Bowel
Disease (IBD), namely Crohn's disease (CD) and ulcerative colitis (UC), but the precise …
Disease (IBD), namely Crohn's disease (CD) and ulcerative colitis (UC), but the precise …
Tofacitinib downregulates TNF and Poly (I: C)-dependent MHC-II expression in the colonic epithelium
S Gopalakrishnan, MD Hansen, HK Skovdahl… - Frontiers in …, 2022 - frontiersin.org
Major Histocompatibility Complex (MHC)-I and-II genes are upregulated in intestinal
epithelial cells (IECs) during active inflammatory bowel diseases (IBD), but little is known …
epithelial cells (IECs) during active inflammatory bowel diseases (IBD), but little is known …
IFNγ induces epithelial reprogramming driving CXCL11-mediated T cell migration
A Cutilli, SA Jansen, F Paolucci, M Mokry, E Mocholi… - bioRxiv, 2024 - biorxiv.org
The cytokine interferon-gamma (IFNγ) plays a multifaceted role in intestinal immune
responses ranging from anti-to pro-inflammatory depending on the setting. Here, using a 3D …
responses ranging from anti-to pro-inflammatory depending on the setting. Here, using a 3D …