The human gastrointestinal tract is in constant contact with microbial stimuli. Its barriers have
to ensure co-existence with the commensal bacteria, while enabling surveillance of intruding …

Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders of the intestinal tract
that have emerged as a growing problem in industrialized countries. Knowledge of IBD …

Introduction The primo vascular system (PVS), an intensive network structure, has been
claimed to be representative of the acupuncture meridian. Here, we explored the role of the …

The intestine is vulnerable to chemotherapy-induced toxicity due to its high epithelial
proliferative rate, making gut toxicity an off-target effect in several cancer treatments …

The complex and dynamic environment of the gastrointestinal tract shapes one of the fastest
renewing tissues in the human body, the intestinal epithelium. Considering the lack of …

The intestine is vulnerable to chemotherapy-induced damage due to the high rate of
intestinal epithelial cell (IEC) proliferation. We have developed a human intestinal organoid …

Background and Aims A key histopathological feature of inflammatory bowel disease is
damage to the mucosa, including breakdown of the epithelial barrier. Human enteroids and …

Background and aims Intestinal fibrosis is a common complication of Inflammatory Bowel
Disease (IBD), namely Crohn's disease (CD) and ulcerative colitis (UC), but the precise …

Major Histocompatibility Complex (MHC)-I and-II genes are upregulated in intestinal
epithelial cells (IECs) during active inflammatory bowel diseases (IBD), but little is known …

The cytokine interferon-gamma (IFNγ) plays a multifaceted role in intestinal immune
responses ranging from anti-to pro-inflammatory depending on the setting. Here, using a 3D …