Many biological investigations require 3D imaging of cells or tissues with nanoscale spatial
resolution. We recently discovered that preserved biological specimens can be physically …

Guidelines, Not Rules 14 Chemical Principles of Accessing Biomolecules in Expansion
Microscopy 14 Accessing Proteins 14 Protein Anchoring with Indirect Readout 14 Protein …

INTRODUCTION Neural circuits across the brain are composed of structures spanning
seven orders of magnitude in size that are assembled from thousands of distinct protein …

Expansion microscopy is a relatively new approach to super-resolution imaging that uses
expandable hydrogels to isotropically increase the physical distance between fluorophores …

Neurophotonics was launched in 2014 coinciding with the launch of the BRAIN Initiative
focused on development of technologies for advancement of neuroscience. For the last …

One of the biggest unsolved questions in neuroscience is how molecules and neuronal
circuitry create behaviors, and how their misregulation or dysfunction results in neurological …

The development of fluorescent labels and powerful imaging technologies in the last two
decades has revolutionized the field of fluorescence microscopy, which is now widely used …

Super-resolution microscopy reveals the molecular organization of biological structures
down to the nanoscale. While it allows the study of protein complexes in single cells, small …

At the cellular level, α-tubulin acetylation alters the structure of microtubules to render them
mechanically resistant to compressive forces. How this biochemical property of microtubule …

Interactions between epithelial cells and neurons influence a range of sensory modalities
including taste, touch, and smell. Vertebrate and invertebrate epidermal cells ensheath …