The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …

In the nervous system, many intracellular responses to elevated calcium are mediated by
CaM kinases (CaMKs), a family of protein kinases whose activities are initially modulated by …

Palmitoylation regulates diverse aspects of neuronal protein trafficking and function. Here a
global characterization of rat neural palmitoyl-proteomes identifies most of the known neural …

The Notch pathway is prominent among those known to regulate neural development in
vertebrates. Notch receptor activation can inhibit neurogenesis, maintain neural progenitor …

Members of the Wnt signaling family are important mediators of numerous developmental
events, including activity-dependent dendrite development, but the pathways regulating …

The development, homeostasis, and regeneration of complex organ systems require
extensive cell–cell communication to ensure that different cells proliferate, migrate …

Synapses are specialized cell–cell contacts that mediate communication between neurons.
Most excitatory synapses in the brain are housed on dendritic spines, small actin-rich …

Bidirectional signaling has emerged as an important signature by which Ephs and ephrins
control biological functions. Eph/ephrin signaling participates in a wide spectrum of …

The polarity and adhesion of radial glial cells (RGCs), which function as progenitors and
migrational guides for neurons, are critical for morphogenesis of the cerebral cortex. These …

Prenatal viral infection has been associated with development of schizophrenia and autism.
Our laboratory has previously shown that viral infection causes deleterious effects on brain …