Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …

After a decade of genome-wide association studies (GWASs), fundamental questions in
human genetics, such as the extent of pleiotropy across the genome and variation in genetic …

During the past 12 years, genome-wide association studies (GWASs) have uncovered
thousands of genetic variants that influence risk for complex human traits and diseases. Yet …

Improved understanding of genetic regulation of the proteome can facilitate identification of
the causal mechanisms for complex traits. We analyzed data on 4,657 plasma proteins from …

A main challenge in genome-wide association studies (GWAS) is to pinpoint possible causal
variants. Results from GWAS typically do not directly translate into causal variants because …

A class of cis-regulatory elements, called enhancers, play a central role in orchestrating
spatiotemporally precise gene-expression programs during development. Consequently …

Genetic variants associated with complex traits are primarily noncoding, and their effects on
gene-regulatory activity remain largely uncharacterized. To address this, we profile …

The emergence of sequence-specific nucleases that enable genome editing is
revolutionizing basic and applied biology. Since the introduction of CRISPR–Cas9, genome …

The most prevalent post-transcriptional mRNA modification, N 6-methyladenosine (m6A),
plays diverse RNA-regulatory roles, but its genetic control in human tissues remains …

Genetic variation associated with disease often appears in non-coding parts of the genome.
Understanding the mechanisms by which this phenomenon leads to disease is necessary to …