Triazoles find applications in several major technological areas, and especially in drug
discovery. The click-chemistry approaches based on Huisgen's cycloaddition reaction are …

Click chemistry has emerged as a valuable tool for rapid compound synthesis, presenting
notable advantages and convenience in the exploration of potential drug candidates. In …

Highlights•Basic mechanism for all the discussed click reaction has been shown.•Many new
enzyme inhibitors was identified by drug discovery using click approaches.•Drug delivery by …

Fragment‐based drug discovery (FBDD) is a method of identifying small molecule hits that
can be elaborated rationally through fragment growing, merging and linking, to afford high …

The highly conserved HIV‐1 transactivation response element (TAR) binds to the trans‐
activator protein Tat and facilitates viral replication in its latent state. The inhibition of Tat …

Kinetic target-guided synthesis (KTGS) is an original discovery strategy allowing a target to
catalyze the irreversible synthesis of its own ligands from a pool of reagents. Although …

For the last 15 years, kinetic target-guided syntheses, including in situ click chemistry, have
been used as alternative methods to find ligands to therapeutically relevant proteins. In this …

The kinetic target-guided synthesis (KTGS) strategy is an unconventional discovery
approach that takes advantage of the presence of the biological target itself in order to …

Kinetic target-guided synthesis (KTGS) is a promising tool for the discovery of biologically
active compounds. It relies on the identification of potent ligands that are covalently …

Different azides and alkynes have been coupled via Cu-catalyzed 1, 3-dipolar Huisgen
cycloaddition to afford a novel family of N 1-and C 5-substituted 1, 2, 3-triazole derivatives …