Genomic DNA is wrapped around a core histone octamer and forms a nucleosome. In
higher eukaryotic cells, strings of nucleosomes are irregularly folded as chromatin domains …

Access to DNA is a prerequisite to the execution of essential cellular processes that include
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …

In eukaryotes, higher-order chromatin organization is spatiotemporally regulated as
domains, for various cellular functions. However, their physical nature in living cells remains …

Eukaryotic chromatin is highly condensed but dynamically accessible to regulation and
organized into subdomains. We demonstrate that reconstituted chromatin undergoes …

The eukaryotic genome is organized within cells as chromatin. For proper information
output, higher-order chromatin structures can be regulated dynamically. How such structures …

Nuclear factors rapidly scan the genome for their targets, but the role of nuclear organization
in such search is uncharted. Here we analyzed how multiple factors explore chromatin …

Although chromatin organization and dynamics play a critical role in gene transcription, how
they interplay remains unclear. To approach this issue, we investigated genome-wide …

Chromatin in eukaryotic cells is a negatively charged polymer composed of DNA, histones,
and various associated proteins. Over the past ten years, our view of chromatin has shifted …

Chromatin structure and dynamics control all aspects of DNA biology yet are poorly
understood, especially at large length scales. We developed an approach, displacement …

The review begins with a concise description of the principles of phase separation. This is
followed by a comprehensive section on phase separation of chromatin, in which we recount …