Evaluation of skin absorption of drugs from topical and transdermal formulations

ALM Ruela, AG Perissinato, MES Lino… - Brazilian journal of …, 2016 - SciELO Brasil
The skin barrier function has been attributed to the stratum corneum and represents a major
challenge in clinical practice pertaining to cutaneous administration of drugs. Despite this, a …

Approaches for breaking the barriers of drug permeation through transdermal drug delivery

A Alexander, S Dwivedi, TK Giri, S Saraf, S Saraf… - Journal of controlled …, 2012 - Elsevier
Transdermal drug delivery system (TDDS) utilizes the skin as executable route for drug
administration but the foremost barrier against drug permeability is the stratum corneum and …

A compliant ionic adhesive electrode with ultralow bioelectronic impedance

L Pan, P Cai, L Mei, Y Cheng, Y Zeng… - Advanced …, 2020 - Wiley Online Library
Simultaneous implementation of high signal‐to‐noise ratio (SNR) but low crosstalk is of
great importance for weak surface electromyography (sEMG) signals when precisely driving …

Design principles of ionic liquids for transdermal drug delivery

EEL Tanner, AM Curreri, JPR Balkaran… - Advanced …, 2019 - Wiley Online Library
Ionic liquids (ILs) and deep eutectic solvents have shown great promise in drug delivery
applications. Choline‐based ILs, in particular choline and geranic acid (CAGE), have been …

Using molecular simulation to understand the skin barrier

P Shamaprasad, CO Frame, TC Moore, A Yang… - Progress in lipid …, 2022 - Elsevier
Skin's effectiveness as a barrier to permeation of water and other chemicals rests almost
entirely in the outermost layer of the epidermis, the stratum corneum (SC), which consists of …

[HTML][HTML] Comparison between Franz diffusion cell and a novel micro-physiological system for in vitro penetration assay using different skin models

I Pulsoni, M Lubda, M Aiello, A Fedi, M Marzagalli… - SLAS technology, 2022 - Elsevier
In vitro diffusive models are an important tool to screen the penetration ability of active
ingredients in various formulations. A reliable assessment of skin penetration enhancing …

Recent advances in nanomaterials for dermal and transdermal applications

A Zoabi, E Touitou, K Margulis - Colloids and Interfaces, 2021 - mdpi.com
The stratum corneum, the most superficial layer of the skin, protects the body against
environmental hazards and presents a highly selective barrier for the passage of drugs and …

[HTML][HTML] Molecular simulation of nonfacilitated membrane permeation

E Awoonor-Williams, CN Rowley - Biochimica et Biophysica Acta (BBA) …, 2016 - Elsevier
This is a review. Non-electrolytic compounds typically cross cell membranes by passive
diffusion. The rate of permeation is dependent on the chemical properties of the solute and …

Quantitative structure-skin permeability relationships

I Tsakovska, I Pajeva, M Al Sharif, P Alov, E Fioravanzo… - Toxicology, 2017 - Elsevier
This paper reviews in silico models currently available for the prediction of skin permeability.
A comprehensive discussion on the developed methods is presented, focusing on …

Molecular dynamics simulation study of permeation of molecules through skin lipid bilayer

R Gupta, DB Sridhar, B Rai - The Journal of Physical Chemistry B, 2016 - ACS Publications
Stratum Corneum (SC), the outermost layer of skin, is mainly responsible for skin's barrier
function. The complex lipid matrix of SC determines these barrier properties. In this study …