Current challenges in de novo plant genome sequencing and assembly | Genome Biology
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Insertions and deletions constitute the second most important source of natural genomic
variation. Insertions and deletions make up to 25% of genomic variants in humans and are …

Multiple structural alignment is a fundamental problem in structural genomics. In this article,
we define a reliable and robust algorithm, MUSTANG (MUltiple STructural AligNment …

Protein structure alignment is a fundamental problem in computational structure biology.
Many programs have been developed for automatic protein structure alignment, but most of …

Even when there is agreement on what measure a protein multiple structure alignment
should be optimizing, finding the optimal alignment is computationally prohibitive. One …

Motivation As protein structure is more conserved than sequence during evolution, multiple
structure alignment can be more informative than multiple sequence alignment, especially …

AAA+ proteins form a large superfamily of P-loop ATPases involved in the energy-
dependent unfolding and disaggregation of macromolecules. In a clustering study aimed at …

Alternative splicing is thought to be one of the major sources for functional diversity in higher
eukaryotes. Interestingly, when mapping splicing events onto protein structures, about half of …

The discovery of broadly neutralizing antibodies (bNAbs) has provided an enormous
impetus to the HIV vaccine research and to entire immunology. The bNAber database at …

Motivation: Superpositioning is an essential technique in structural biology that facilitates the
comparison and analysis of conformational differences among topologically similar …