Puerarin, an isoflavone glycoside derived from Pueraria lobata (Willd.) Ohwi, has been
identified as a pharmacologically active component with diverse benefits. A large number of …

Type 2 diabetes mellitus is a disease that affects many metabolic pathways. It is associated
with insulin resistance, impaired insulin signaling, β-cell dysfunction, abnormal glucose …

Da Silva et al. showed that the triglyceride-glucose (TyG) index was positively associated
with a higher prevalence of symptomatic coronary artery disease (CAD). TyG has been used …

Ischemia–reperfusion injury (IRI) is one of the biggest challenges for cardiovascular
researchers given the huge death toll caused by myocardial ischemic disease …

The total antioxidant capacity (TAC) is a key indicator of the body's resistance to oxidative
stress injury in diabetic patients. The measurement of TAC is important for effectively …

Aims The aim of this study was to identify the molecular mechanism for hyperglycaemia-
induced metabolic memory in endothelial cells (ECs), and to show its critical importance to …

Rationale: Vascular calcification is a serious cardiovascular complication that contributes to
the increased morbidity and mortality of patients with diabetes mellitus. Hyperglycemia, a …

Background Observational series suggest a mortality benefit from metformin in the heart
failure (HF) population. However, the benefit of metformin in HF with preserved ejection …

Vascular calcification is accelerated in patients with diabetes mellitus and increases risk of
cardiovascular events and mortality. Vascular smooth muscle cells (VSMC) play a key role in …

Scope Xanthohumol (XN) is a bioactive prenylflavonoid from hops. A single‐dose
pharmacokinetic (PK) study was conducted in men (n= 24) and women (n= 24) to determine …