Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …

Nanomedicine has been extensively explored to enhance the efficacy of chemotherapy with
modest therapeutic efficacy in the clinic, owing to various factors. A primary factor is …

Nanoparticles have been widely used in tumor targeted drug delivery, while the antitumor
effects are not always satisfactory due to the limited penetration and retention. As we all …

Photoacoustic (PA) imaging has emerged as a powerful technique for the high resolution
visualization of biological processes within deep tissue. Through the development and …

The tumor-associated vasculature imposes major structural and biochemical barriers to the
infiltration of effector T cells and effective tumor control. Correlations between stimulator of …

Hyaluronic acid (HA) is a natural polysaccharide that has gained much attention due to its
biocompatibility, enzyme degradation capacity and active tumor targeting capacity. Its …

Tumor penetration is important for effectively tumor targeting drug delivery. Recently, many
researches are published to overcome the barriers that restrict tumor penetration and …

Chemotherapy remains restricted by poor drug delivery efficacy due to the heterogenous
nature of tumor. Herein, we presented a novel nanoparticle that could not only response to …

Conventional cancer treatments, such as surgical resection, radiotherapy, and
chemotherapy, have achieved significant progress in cancer therapy. Nevertheless, some …

The delivery of drugs to tumors by nanoparticles is a rapidly growing field. However, the
complex tumor microenvironment (TME) barriers greatly hinder drug delivery to tumors. In …