Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials

J Liu, Y Wang, Y Akamatsu, CC Lee, RA Stetler… - Progress in …, 2014 - Elsevier
The brain vasculature has been increasingly recognized as a key player that directs brain
development, regulates homeostasis, and contributes to pathological processes. Following …

Impact of microRNAs on ischemic stroke: from pre-to post-disease

G Li, KC Morris-Blanco, MS Lopez, T Yang… - Progress in …, 2018 - Elsevier
Stroke is the number one cause of neurological dysfunction in adults and has a heavy
socioeconomic burden worldwide. The etiological origins of ischemic stroke and resulting …

Mapping the fine-scale organization and plasticity of the brain vasculature

C Kirst, S Skriabine, A Vieites-Prado, T Topilko… - Cell, 2020 - cell.com
The cerebral vasculature is a dense network of arteries, capillaries, and veins. Quantifying
variations of the vascular organization across individuals, brain regions, or disease models …

Angiogenesis after ischemic stroke

J Fang, Z Wang, C Miao - Acta Pharmacologica Sinica, 2023 - nature.com
Owing to its high disability and mortality rates, stroke has been the second leading cause of
death worldwide. Since the pathological mechanisms of stroke are not fully understood …

Functional dissection of astrocyte-secreted proteins: Implications in brain health and diseases

MK Jha, JH Kim, GJ Song, WH Lee, IK Lee… - Progress in …, 2018 - Elsevier
Astrocytes, which are homeostatic cells of the central nervous system (CNS), display
remarkable heterogeneity in their morphology and function. Besides their physical and …

MicroRNA-210 overexpression induces angiogenesis and neurogenesis in the normal adult mouse brain

L Zeng, X He, Y Wang, Y Tang, C Zheng, H Cai, J Liu… - Gene therapy, 2014 - nature.com
Angiogenesis and neurogenesis are crucial processes for brain tissue repair and
remodeling after brain injury. Current study shows that microRNA-210 (miR-210) promotes …

Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke

R Rust, L Grönnert, C Gantner… - Proceedings of the …, 2019 - National Acad Sciences
Stroke is a major cause of serious disability due to the brain's limited capacity to regenerate
damaged tissue and neuronal circuits. After ischemic injury, a multiphasic degenerative and …

MicroRNA-126 regulates angiogenesis and neurogenesis in a mouse model of focal cerebral ischemia

M Qu, J Pan, L Wang, P Zhou, Y Song, S Wang… - … Therapy-Nucleic Acids, 2019 - cell.com
Studies demonstrate that microRNA-126 plays a critical role in promoting angiogenesis.
However, its effects on angiogenesis following ischemic stroke are unclear. Here, we …

Rehabilitation and plasticity following stroke: insights from rodent models

M Caleo - Neuroscience, 2015 - Elsevier
Ischemic injuries within the motor cortex result in functional deficits that may profoundly
impact activities of daily living in patients. Current rehabilitation protocols achieve only …

Pro‐and antiangiogenic therapies: current status and clinical implications

R Rust, C Gantner, ME Schwab - The FASEB Journal, 2019 - Wiley Online Library
Blood vessels nurture every part of the human body. Consequently, abnormalities in the
vasculature are closely associated with a variety of diseases, including cerebral stroke, heart …